- ►inotekcorp.com [PDF] WL Suarez-Pinzon, JG Mabley, R Power, C … - Diabetes, 2003 - Am Diabetes Assoc Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that consumes NAD in
response to DNA strand breaks. The PARP inhibitor nicotinamide prevents NAD
consumption and protects islet β-cells from chemically induced necrosis ... Cited by 28 - Related articles - BL Direct - All 9 versions
- ►aspetjournals.org GS Scott, RB Kean, T Mikheeva, MJ Fabis, … - Journal of Pharmacology and Experimental …, 2004 - ASPET Poly(ADP-ribose) polymerase (PARP) activity has been implicated in the
pathogenesis of several central nervous system (CNS) disorders. For example, the
presence of extensive poly(ADP)ribosylation in CNS tissues from animals ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►inotekcorp.com [PDF] JG Mabley, P Jagtap, M Perretti, SJ Getting, … - Inflammation Research, 2001 - Springer Abstract. Objective and design: Oxygen- and nitrogen- derived free radicals and
oxidants play an important role in the pathogenesis of various forms of
inflammation. Recent work emphasizes the importance of oxidant-induced DNA ... Cited by 82 - Related articles - BL Direct - All 7 versions
A Chiarugi - British journal of pharmacology, 2002 - pubmedcentral.nih.gov This study investigated the effect of the PARP-1 inhibitors
6(5H)-phenanthridinone and benzamide as well as that of benzoic acid, an
inactive analogue of benzamide, on development of experimental allergic ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Gonzalez, M de Murcia… - Diabetes, 2002 - Am Diabetes Assoc Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that consumes NAD in
response to DNA strand breaks. Its excessive activation seems particularly
deleterious to pancreatic ß-cells, as exemplified by the complete ... Cited by 11 - Related articles - BL Direct - All 5 versions
JG Mabley, WL Suarez-Pinzon, G Haskó, AL … - British journal of pharmacology, 2001 - pubmedcentral.nih.gov Activation of poly(ADP-ribose) synthetase (PARS, also termed polyADP-ribose
polymerase or PARP) has been proposed as a major mechanism contributing to
β-cell destruction in type I diabetes. In the present study, we have ... Cited by 39 - Related articles - BL Direct - All 9 versions
T Kuchmerovska, I Shymanskyy, G Donchenko … - Journal of diabetes and its complications, 2004 - Elsevier The study has been undertaken to evaluate the effect of streptozotocin
(STZ)-induced diabetes on rat brain poly(ADP-ribose)polymerase (Parp) activity
and assess whether and how a Parp inhibitor, nicotinamide (NAm), may ... Cited by 12 - Related articles - All 6 versions
D Ferraris, RP Ficco, D Dain, M Ginski, S … - Bioorganic & medicinal chemistry, 2003 - Elsevier A class of poly(ADP-ribose) polymerase (PARP-1) inhibitors, the
imidazobenzodiazepines, are presented in this text. Several derivatives were
designed and synthesized with ionizable groups (ie, tertiary amines) in ... Cited by 16 - Related articles - All 4 versions
- ►aspetjournals.org [PDF] A Iwashita, N Tojo, S Matsuura, S Yamazaki, … - Journal of Pharmacology and Experimental …, 2004 - ASPET Page 1. Revised MS (JPET/2004/066944) 1 A Novel and Potent PARP-1 Inhibitor,
5-chloro-2-[3-(4-phenyl-3, 6-dihydro-1(2H)-pyridinyl ... Cited by 3 - Related articles - All 2 versions
