RA Ritzel, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by a relative β-cell deficit as a result of increased β-cell
apoptosis and islet amyloid derived from the β-cell peptide islet amyloid polypeptide (IAPP). Human
IAPP (h-IAPP) but not mouse IAPP ... Cited by 75 - Related articles - BL Direct - All 9 versions
AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass. In contrast, obese
humans with type 2 diabetes have an ∼60% deficit in β-cell mass. Recent studies in rodents reveal
that β-cell mass is regulated, ... Cited by 146 - Related articles - BL Direct - All 6 versions
AE Butler, J Jang, T Gurlo, MD Carty, WC Soeller, PC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass, increased β-cell
apoptosis, and impaired insulin secretion. Also, islets in type 2 diabetes often contain deposits of
islet amyloid derived from islet ... Cited by 93 - Related articles - BL Direct - All 9 versions
S Zhang, J Liu, EL Saafi, GJS Cooper - FEBS letters, 1999 - Elsevier Human amylin (10 μM) significantly inhibited RINm5F islet β-cell proliferation and evoked
apoptosis associated with typical degenerative ultrastructural changes and DNA fragmentation,
whereas rat amylin did not. Time ... Cited by 42 - Related articles - All 6 versions
J Janson, RH Ashley, D Harrison, S McIntyre, … - DIABETES-NEW …, 1999 - Am Diabetes Assoc NIDDM is characterized by islet amyloid deposits and decreased -cell mass. Islet amyloid is derived
from the locally expressed protein islet amyloid polypeptide (IAPP). While it is now widely accepted
that abnormal aggregation of IAPP ... Cited by 228 - Related articles - BL Direct - All 7 versions
JJ Meier, RA Ritzel, K Maedler, T Gurlo, PC Butler - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Beta cell destruction in type 1 diabetes is apparently mediated by the
release of cytokines. We questioned whether cytokine-induced apoptosis pref- erentially kills
replicating beta cells. Materials ... Cited by 16 - Related articles - BL Direct - All 3 versions
M Couce, LA Kane, TD O'Brien, J Charlesworth, W … - Diabetes, 1996 - Am Diabetes Assoc Islet amyloid derived from islet amyloid polypeptide (IAPP) is a well-recognized feature of type II
diabetes. However, the mechanism of islet amyloidogenesis is unknown. In vitro studies suggest that
amino acid residues 20-29 in human, ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►pnas.org [PDF] J Janson, WC Soeller, PC Roche, RT … - Proceedings of the …, 1996 - National Acad Sciences Proc. Natl. Acad. Sci. USA Vol. 93, pp. 7283-7288, July 1996 Medical Sciences ... Spontaneous
diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide ... JULIETrE
JANSON*, WALTER C. SOELLERt, ... Cited by 136 - Related articles - BL Direct - All 11 versions
MR Hayden - JOP. J Pancreas (Online), 2002 - joplink.net The presence of amyloid within the islet of the pancreas may be one of the best kept secrets in
clinical medicine and translation of this century old finding may help to better understand the
progressive nature of type 2 ... Cited by 39 - Related articles - Cached - All 6 versions
EL Saafi, B Konarkowska, S Zhang, J Kistler, GJS … - Cell Biology International, 2001 - Elsevier A view is emerging that human amylin (HA) kills pancreatic islet β-cells by apoptosis. This study
strengthens this view by documenting time-dependent morphological and ultrastructural changes in 10
μ HA-treated cultured RINm5F islet ... Cited by 55 - Related articles - BL Direct - All 4 versions
