H Noguchi, H Kaneto, GC Weir, S Bonner-Weir - Diabetes, 2003 - Am Diabetes Assoc The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1, a
homeodomain-containing transcription factor, plays a central role in regulating pancreatic
development and insulin gene ... Cited by 109 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org H Noguchi, S Bonner-Weir, FY Wei, M Matsushita, S … - Diabetes, 2005 - Am Diabetes Assoc BETA2/NeuroD, a basic helix-loop-helix transcription factor, is a key regulator of pancreatic islet
morphogenesis and insulin gene transcription. Here we report for the first time that the
BETA2/NeuroD protein can permeate ... Cited by 35 - Related articles - BL Direct - All 6 versions
H Noguchi, M Matsushita, S Matsumoto, YF Lu, H … - … and Biophysical Research …, 2005 - Elsevier PDX-1 plays a central role in differentiation of insulin-producing cells. We previously reported
that exogenous PDX-1 protein can permeate cells and induce insulin gene expression in progenitor
cells. These data suggest a ... Cited by 26 - Related articles - All 6 versions
H Noguchi, M Matsushita, T Okitsu, A Moriwaki, K … - Nature medicine, 2004 - nature.com 1 Department of Physiology and Transplant and Surgical Oncology, Okayama University Graduate School
of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558 Japan. ... 2 Department of
Gastroenterological Surgery, ... Cited by 95 - Related articles - BL Direct - All 4 versions
H Noguchi, S Matsumoto, T Okitsu, Y Iwanaga, … - Cell …, 2005 - ingentaconnect.com PDX-1 plays a central role in regulating insulin gene transcription and differentiation of
insulin-producing cells. It was previously reported that, due to its own Antennapedia-like protein
transduction domain (PTD), ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org J Domínguez-Bendala, D Klein, M Ribeiro, C Ricordi, L … - Diabetes, 2005 - Am Diabetes Assoc Stem cell technologies hold great potential for the treatment of type 1 diabetes, provided that
functional transplantable ß-cells can be selectively generated in an efficient manner. Such a
process should recapitulate, at ... Cited by 44 - Related articles - All 5 versions
H Taniguchi, E Yamato, F Tashiro, H Ikegami, T … - Gene Therapy, 2003 - nature.com -cell neogenesis is expected to provide a new therapy for diabetes. Numerous studies have
demonstrated that transcriptional regulation involving pdx-1 is essential for endocrine neogenesis
in vivo and in vitro. Therefore, it ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►pnas.org AM Holland, MA Hale, H Kagami, RE … - Proceedings of the …, 2002 - National Acad Sciences To investigate the role of the HOX-like homeoprotein PDX1 in the formation and maintenance of the
pancreas, we have genetically engineered mice so that the only source of PDX1 is a transgene that
can be controlled by the ... Cited by 90 - Related articles - BL Direct - All 13 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, Y … - … and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in inducing differentiation
into insulin-producing cells has been demonstrated in some cells and tissues. In order to carry out
efficient screening of somatic ... Cited by 46 - Related articles - All 6 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T Matsuoka, M … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients
worldwide is increasing. The reduction of insulin biosynthesis in pancreatic β-cells is closely
associated with the onset and ... Cited by 54 - Related articles - All 6 versions
