A Kubaszek, J Pihlajamäki, V Komarovski, V Lindi, J … - Diabetes, 2003 - Am Diabetes Assoc High levels of cytokines are risk factors for type 2 diabetes. Therefore, we investigated whether
the promoter polymorphisms of the tumor necrosis factor-α (TNF-α; G-308A) and interleukin 6
(IL-6; C-174G) genes predict the conversion from impaired glucose tolerance (IGT) to type ... Cited by 104 - Related articles - BL Direct - All 5 versions
B Vozarova, JM Fernández-Real, WC Knowler, L … - Human genetics, 2003 - Springer Abstract Chronic low-grade activation of the immune system may play a role in the pathogenesis
of type-2 dia- betes mellitus (T2DM). Interleukin-6 (IL6), a powerful inducer of hepatic acute phase
response, has been impli- cated in the etiology of insulin resistance and T2DM. Re- ... Cited by 105 - Related articles - BL Direct - All 4 versions
A Kubaszek, J Pihlajamäki, K Punnonen, P Karhapää, I … - Diabetes, 2003 - Am Diabetes Assoc Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in many tissues. IL-6 null mice show low
energy expenditure, but the effect of the variants of the IL-6 gene on energy expenditure has
not been previously studied in humans. Therefore, we investigated the effect of the ... Cited by 92 - Related articles - BL Direct - All 4 versions
- ►endojournals.org [PDF] M Mohlig, H Boeing, J Spranger, M Osterhoff, A … - Journal of Clinical …, 2004 - Endocrine Soc Increased levels of IL-6 add further risk to the impact of obe- sity in respect to the development
of type 2 diabetes mellitus (T2DM). A C-174G polymorphism within the IL-6 promoter region was
shown to influence transcription rate of IL-6. We made use of a nested case-control study ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►endojournals.org [PDF] T Illig, F Bongardt, A Schopfer, S Muller-Scholze … - Journal of Clinical …, 2004 - Endocrine Soc Elevated blood concentrations of IL-6 have been shown to predict type 2 diabetes. Because
the impact of IL-6 gene poly- morphisms on diabetes status, parameters of the metabolic
syndrome, and low-grade systemic inflammation has not been analyzed in a population- ... Cited by 47 - Related articles - BL Direct - All 4 versions
JM Fernández-Real, M Broch, J Vendrell, C Gutiérrez, … - Diabetes, 2000 - Am Diabetes Assoc Type 2 diabetes and the insulin resistance syndrome have been hypothesized to constitute manifestations
of an ongoing acute-phase response. We aimed to study an interleukin-6 (IL-6) gene polymorphism
in relation to insulin sensitivity (I L-6 is the main cytokine involved in an acute-phase ... Cited by 184 - Related articles - BL Direct - All 3 versions
BT Heijmans, RG Westendorp, S Droog, C Kluft, … - Genes and …, 2002 - ncbi.nlm.nih.gov Ample evidence supports a role for tumour necrosis factor alpha (TNFalpha) in the development
of type 2 diabetes and cardiovascular disease. TNFalpha expression was found to be influenced
by a -308G/A polymorphism in the promoter of the gene encoding TNFalpha (TNF). We ... Cited by 30 - Related articles - BL Direct - All 2 versions
YH Hamid, CS Rose, SA Urhammer, C Glümer, R … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The cytokine interleukin 6 (IL-6) is an essential regulator of the acute
phase response associated with insulin-resistant states including type 2 diabetes and
obesity. Three polymorphisms at positions −597, −572, and −174 of the IL6 promoter ... Cited by 69 - Related articles - All 4 versions
- ►physiology.org [PDF] JA McKenzie, EP Weiss, IA Ghiu, O … - Journal of Applied …, 2004 - Am Physiological Soc 30 articles, 22 of which you can access free at: This article cites http://jap.physiology.org/cgi/content
/full/97/4/1338#BIBL ... 3 other HighWire hosted articles: This article has been cited by ...
[PDF] [Full Text] [Abstract] , September 13, 2005; 102 (37): 13260-13265. PNAS Ballinger ... Cited by 25 - Related articles - BL Direct - All 7 versions
O Laukkanen, J Pihlajamäki, J Lindström, J Eriksson, … - Diabetologia, 2004 - Springer Aims/hypothesis. Type 2 diabetes is a complex disorder with strong heritability. The aim of our
study was to in- vestigate whether common polymorphisms in the genes regulating the early
insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; ... Cited by 29 - Related articles - BL Direct - All 7 versions
