- ►diabetesjournals.org BA Spurlin, RM Thomas, AK Nevins, HJ Kim, YJ Kim, … - Diabetes, 2003 - Am Diabetes Assoc To investigate the physiological effects of modulating the abundance of Munc18c or syntaxin
4 (Syn4) proteins on the regulation of glucose homeostasis in vivo, we generated
tetracycline-repressible transgenic mice that overexpress either Munc18c or Syn4 ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov C Yang, KJ Coker, JK Kim, S Mora, DC … - Journal of Clinical …, 2001 - Am Soc Clin Investig To investigate the physiological function of syntaxin 4 in the regulation of GLUT4 vesicle
trafficking, we used homologous recombination to generate syntaxin 4–knockout mice. Homozygotic
disruption of the syntaxin 4 gene results in early embryonic lethality, whereas ... Cited by 63 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org BA Spurlin, SY Park, AK Nevins, JK Kim, DC Thurmond - Diabetes, 2004 - Am Diabetes Assoc Insulin-stimulated translocation of GLUT4 vesicles from an intracellular compartment to the plasma
membrane in 3T3L1 adipocytes is mediated through a syntaxin 4 (Syn4)- and Munc18c-dependent
mechanism. To investigate the impact of increasing Syn4 protein abundance on glucose ... Cited by 19 - Related articles - BL Direct - All 5 versions
T Saito, S Okada, E Yamada, K Ohshima, H … - Journal of Biological …, 2003 - ASBMB Although syntaxin 1 is generally thought to function as the primary target-N-ethylmaleimide-sensitive
factor attachment protein receptor required for pancreatic cell insulin secretion, we have observed
that overexpression of a dominant-interfering syntaxin 4 mutant (syntaxin 4/ TM) ... Cited by 22 - Related articles - BL Direct - All 4 versions
D C. Thurmond, Jeffrey E. Pessin - Molecular membrane …, 2001 - Informa Pharma Science Page 1. Molecular machinery involved in the insulin-regulated fusion of GLUT4-
containing vesicles with the plasma membrane (Review) Debbie C. Thurmond{ and
Jeffrey E. Pessin{* {Indiana University School of Medicine, Department ... Cited by 62 - Related articles - BL Direct - All 6 versions
E Oh, BA Spurlin, JE Pessin, DC Thurmond - Diabetes, 2005 - Am Diabetes Assoc The disruption of Munc18c binding to syntaxin 4 impairs insulin-stimulated GLUT4 vesicle translocation
in 3T3L1 adipocytes. To investigate the physiological function and requirement for Munc18c
in the regulation of GLUT4 translocation and glucose homeostasis in vivo, we used ... Cited by 34 - Related articles - All 6 versions
- ►endojournals.org BA Spurlin, DC Thurmond - Molecular Endocrinology, 2006 - Endocrine Soc Numerous overexpression studies have recently implicated Syntaxin 4 as an effector of insulin
secretion, although its requirement in insulin granule exocytosis is unknown. To address
this, islets from Syntaxin 4 heterozygous (–/+) knockout mice were isolated and compared ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►jbc.org AK Nevins, DC Thurmond - Journal of Biological Chemistry, 2005 - ASBMB In pancreatic beta cells, insulin granule exocytosis is regulated by SNARE (soluble
N-ethylmaleimide-sensitive factor attachment protein receptor protein (SNAP) receptor)
proteins, and this is coupled to cortical F-actin reorganization via the Rho family GTPase ... Cited by 37 - Related articles - All 5 versions
- ►nih.gov DC Thurmond, M Kanzaki, AH Khan, JE … - Molecular and Cellular …, 2000 - Am Soc Microbiol To examine the functional role of the interaction between Munc18c and syntaxin 4 in the regulation
of GLUT4 translocation in 3T3L1 adipocytes, we assessed the effects of introducing three different
peptide fragments (20 to 24 amino acids) of Munc18c from evolutionarily conserved ... Cited by 78 - Related articles - BL Direct - All 4 versions
Y Tamori, M Kawanishi, T Niki, H Shinoda, S Araki, … - Journal of Biological …, 1998 - ASBMB Insulin induces the translocation of vesicles containing the glucose transporter GLUT4 from an
intracellular compartment to the plasma membrane in adipocytes. SNARE proteins have been
implicated in the docking and fusion of these vesicles with the cell membrane. The role of ... Cited by 102 - Related articles - BL Direct - All 7 versions
