YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB … - Diabetes, 2003 - Am Diabetes Assoc In humans with obesity or type 2 diabetes, insulin target tissues are resistant
to many actions of insulin. The atypical protein kinase C (PKC) isoforms λ and
ζ are downstream of phosphatidylinositol-3 kinase (PI3K) and are required ... Cited by 79 - Related articles - BL Direct - All 5 versions
M Beeson, MP Sajan, M Dizon, D Grebenev, J … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance in type 2 diabetes is partly due to impaired glucose
transport in skeletal muscle. Atypical protein kinase C (aPKC) and protein
kinase B (PKB), operating downstream of phosphatidylinositol (PI) 3-kinase ... Cited by 90 - Related articles - BL Direct - All 4 versions
YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB … - Diabetes, 2003 - Am Diabetes Assoc Page 1. Insulin-Stimulated Protein Kinase C / Activity Is Reduced in Skeletal Muscle
of Humans With Obesity and Type 2 Diabetes Reversal With Weight Reduction ... Cited by 13 - Related articles
ML Standaert, HK Ortmeyer, MP Sajan, Y … - Diabetes, 2002 - Am Diabetes Assoc Rhesus monkeys frequently develop obesity and insulin resistance followed by
type 2 diabetes when allowed free access to chow. This insulin resistance is
partly due to defective glucose transport into skeletal muscle. In this ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►endojournals.org G Bandyopadhyay, Y Kanoh, MP Sajan, ML … - Endocrinology, 2000 - Endocrine Soc We used adenoviral gene transfer methods to evaluate the role of atypical
protein kinase Cs (PKCs) during insulin stimulation of glucose transport in L6
myotubes. Expression of wild-type PKC- potentiated maximal and half-maximal ... Cited by 79 - Related articles - BL Direct - All 2 versions
- ►endojournals.org Y Kanoh, MP Sajan, G Bandyopadhyay, A … - Endocrinology, 2003 - Endocrine Soc Insulin-stimulated glucose transport in skeletal muscle is thought to be
effected at least partly through atypical protein kinase C isoforms (aPKCs)
operating downstream of phosphatidylinositol (PI) 3-kinase and 3- ... Cited by 29 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org P Vollenweider, B Ménard, P Nicod - Diabetes, 2002 - Am Diabetes Assoc Impaired glucose tolerance (IGT) is characterized by insulin resistance.
Recently, defects in the insulin-signaling cascade have been implicated in the
pathogenesis of insulin resistance. To study insulin signaling in IGT, we ... Cited by 88 - Related articles - BL Direct - All 5 versions
- ►endojournals.org Y Kanoh, G Bandyopadhyay, MP Sajan, ML … - Endocrinology, 2001 - Endocrine Soc Atypical protein kinases C (PKCs), and , and protein kinase B (PKB) are thought
to function downstream of phosphatidylinositol 3-kinase (PI 3-kinase) and
regulate glucose transport during insulin action in skeletal muscle and ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MP Sajan, ML Standaert, A Miura, G … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Insulin resistance in obesity is partly due to diminished glucose transport in
myocytes and adipocytes, but underlying mechanisms are uncertain.
Insulin-stimulated glucose transport requires activation of ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►nih.gov YB Kim, SE Nikoulina, TP Ciaraldi, RR Henry … - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig To determine whether the serine/threonine kinase Akt (also known as protein
kinase B) is activated in vivo by insulin administration in humans, and whether
impaired activation of Akt could play a role in insulin resistance, we ... Cited by 262 - Related articles - BL Direct - All 10 versions
