- ►diabetesjournals.org G Li, CV Mobbs, PJ Scarpace - Diabetes, 2003 - Am Diabetes Assoc Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and
hyperinsulinemic. For testing whether chronic activation of the central
melanocortin pathway can bypass the defective leptin signaling and ... Cited by 39 - Related articles - BL Direct - All 5 versions
G Li, Y Zhang, JT Wilsey, PJ Scarpace - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Age-related obesity is asso- ciated with impaired
hypothalamic pro-opiomelanocortin (Pomc) gene expression. We assessed whether
overproduc- tion of POMC in the hypothalamus ameliorates age-related ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►endojournals.org P Cettour-Rose, F Rohner-Jeanrenaud - Endocrinology, 2002 - Endocrine Soc The effects of a 3-d peripheral administration of an -MSH agonist, MTII, on body
weight and the expression of uncoupling proteins (UCPs) and carnitine
palmitoyltransferase-1 were determined in lean and genetically obese fa/fa ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►endojournals.org E Savontaus, TL Breen, A Kim, LM Yang, SC … - Endocrinology, 2004 - Endocrine Soc The proopiomelanocortin-derived peptide, -MSH, inhibits feeding via melanocortin
receptors in the hypothalamus and genetic defects inactivating the melanocortin
system have been shown to lead to obesity in experimental animals and ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DD Pierroz, M Ziotopoulou, L Ungsunan, S … - Diabetes, 2002 - Am Diabetes Assoc High-fat diet-induced obesity (DIO) in rodents is associated with
hyperleptinemia and resistance to leptin, but the response to agents acting
downstream of leptin receptors remains unknown. We assessed the response of ... Cited by 102 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] G Li, Y Zhang, JT Wilsey, PJ Scarpace - Journal of Endocrinology, 2004 - Soc Endocrinology The effects of the chronic activation of the central melano- cortin (MC) system
by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF)
diet-induced obese (DIO) Sprague–Dawley rats. Six-day central infusion of ... Cited by 31 - Related articles - BL Direct - All 4 versions
Y Zhang, M Matheny, N Tümer, PJ Scarpace - Neurobiology of aging, 2004 - Elsevier To address whether defective melanocortin activation is one element of leptin
resistance with age, we infused centrally the melanocortin agonist, MTII and
antagonist, SHU9119 in young and old rats. Food intake, energy expenditure, ... Cited by 27 - Related articles - All 9 versions
- ►146.203.52.26 [PDF] TM Mizuno, KA Kelley, GM Pasinetti, JL … - Diabetes, 2003 - Am Diabetes Assoc Hypothalamic proopiomelanocortin (POMC) gene expression is reduced in many forms
of obesity and diabetes, particularly in those attributable to deficiencies in
leptin or its receptor. To assess the functional significance of POMC in ... Cited by 36 - Related articles - BL Direct - All 5 versions
PJ Scarpace, M Matheny, Y Zhang, N Tümer, … - Neuropharmacology, 2002 - Elsevier The purpose of this study was to determine if long-term leptin treatment
desensitizes leptin signal transduction and the subsequent downstream anorexic
and thermogenic responses in normal and leptin-resistant age-related obese ... Cited by 47 - Related articles - BL Direct - All 5 versions
S Blüher, M Ziotopoulou, JW Bullen, SJ … - Diabetes, 2004 - Am Diabetes Assoc To elucidate mechanisms of melanocortin action, we investigated the effects of a
melanocortin receptor agonist (melanotetan II [MTII]) in lean C57BL/6J and obese
(DIO, ob/ob, UCP1-DTA) mice. MTII administration (100 μg qidip) for 24 h ... Cited by 52 - Related articles - BL Direct - All 5 versions
