- ►diabetesjournals.org M Rossmeisl, JS Rim, RA Koza, LP Kozak - Diabetes, 2003 - Am Diabetes Assoc C57BL/6J (B6) and AKR/J (AKR) inbred strains of mice develop a comparable degree
of obesity when fed a high-fat diet. However, although obese B6 mice are more
glucose intolerant, obese AKR mice are more insulin resistant. To ... Cited by 64 - Related articles - BL Direct - All 4 versions
T Kayo, H Fujita, J Nozaki… - Comparative medicine, 2000 - ncbi.nlm.nih.gov BACKGROUND AND PURPOSE: Our objective was to map the genes responsible for poor
glucose tolerance in a C57BL/6 (B6) mouse model, which provides a human model of
non-insulin-dependent diabetes mellitus. Insulin secretion was found to be ... Cited by 16 - Related articles - BL Direct
- ►endojournals.org S Kooptiwut, S Zraika, AW Thorburn, ME … - Endocrinology, 2002 - Endocrine Soc REDUCED GLUCOSE-MEDIATED INSULIN secretion is an essential and characteristic
feature of type 2 diabetes (1). The causes of ß-cell dysfunction are not known,
although there is evidence suggesting that ß-cell failure may be preceded ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org RN Kulkarni, K Almind, HJ Goren, JN Winnay, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is a complex disease in which genetic and environmental factors
interact to produce alterations in insulin action and insulin secretion, leading
to hyperglycemia. To evaluate the influence of genetic background on ... Cited by 65 - Related articles - BL Direct - All 8 versions
- ►pubget.com [PDF] AA Toye, JD Lippiat, P Proks, K Shimomura, L … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 675–686 DOI 10.1007/s00125-005-1680-z ARTICLE AA
Toye . JD Lippiat . P. Proks . K. Shimomura . L.Bentley . A. Hugill . ... Cited by 57 - Related articles - All 4 versions
- ►physiology.org B Ahren, G Pacini - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc This study evaluated the relative contribution of insulin-dependent mechanisms
vs. mechanisms independent on dynamic insulin for glucose intolerance induced by
high-fat diet. C57BL/6J mice underwent a frequently sampled intravenous ... Cited by 28 - Related articles - BL Direct - All 5 versions
K Almind, RN Kulkarni, SM Lannon, CR Kahn - Diabetes, 2003 - Am Diabetes Assoc Mice double heterozygous (DH) for deletion of insulin receptor and insulin
receptor substrate-1 are lean, insulin resistant, and have a phenotype that
strongly depends on the genetic background of the mouse. On the C57BL/6 ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►cell.com H Freeman, K Shimomura, E Horner, RD Cox, … - Cell Metabolism, 2006 - Elsevier The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion.
QTL mapping identified Nicotinamide Nucleotide Transhydrogenase (Nnt), a
nuclear-encoded mitochondrial protein thought to be involved in free ... Cited by 66 - Related articles - All 13 versions
- ►diabetesjournals.org K Almind, CR Kahn - Diabetes, 2004 - Am Diabetes Assoc Diet-induced obesity is the primary determinant of the current epidemic of
diabetes. We have explored the role of genetics in this phenomenon, using
C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 × 129)F2 mice on a ... Cited by 54 - Related articles - BL Direct - All 6 versions
