SG Laychock, Y Tian, SM Sessanna - Diabetes, 2003 - Am Diabetes Assoc The endothelial differentiation gene (EDG) receptors are a class of G protein-coupled
receptors. EDG-1, -3, -5, -6, and -8 bind the bioactive lipid sphingosine-1-phosphate (SPP) as
the primary signaling ligand. EDG-2, -4, and -7 bind the ligand lysophosphatidic acid. ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►endojournals.org SG Laychock, SM Sessanna, MH Lin, LD Mastrandrea - Endocrinology, 2006 - Endocrine Soc Cytokines mediate pancreatic islet ß-cell apoptosis and necrosis, leading to loss of insulin secretory
capacity and type 1 diabetes mellitus. The cytokines, IL-1ß and interferon- , induced terminal
deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling ... Cited by 14 - Related articles - BL Direct - All 4 versions
H Shimizu, F Okajima, T Kimura, K Ohtani, T … - ENDOCRINE …, 2000 - sciencelinks.jp Abstract;Sphingosine is involved in the regulation of cellular processes as a second messenger
in various kinds of cells. Since the possible involvement of sphingosine has not been investigated
in pancreatic .BETA.-cells, we determined the expression of putative sphingosine 1- ... Cited by 5 - Related articles - Cached - BL Direct - All 2 versions
- ►diabetesjournals.org LD Mastrandrea, SM Sessanna, SG Laychock - Diabetes, 2005 - Am Diabetes Assoc Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with the potential to mobilize Ca
2+ , to inhibit apoptosis, and to promote mitogenesis. Sphingosine kinase (SPHK) and S1P were
characterized in INS-1 insulinoma cells and isolated rat islets of Langerhans. SPHK ... Cited by 21 - Related articles - All 5 versions
- ►diabetesjournals.org [PDF] CD Major, ZY Gao, BA Wolf - Diabetes, 1999 - Am Diabetes Assoc Activation of the sphingomyelin/ceramide pathway may mediate interleukin-1–induced -cell death
(Welsh, N: I nterleuken - 1 –induced ceramide and diacylglycerol generation may lead to activation
of the c-Jun NH2- terminal kinase and the transcription factor ATF-2 in the ... Cited by 17 - Related articles - BL Direct - All 7 versions
M Xia, SG Laychock - Diabetes, 1993 - Am Diabetes Assoc Glucose-induced insulin secretion is desensitized during long-term exposure of pancreatic islet
beta-cells to elevated glucose levels. This study characterizes an in vitro model of glucose-induced
desensitization in cultured isolated islets of the rat. Insulin secretion in desensitized islets ... Cited by 33 - Related articles - BL Direct - All 5 versions
F Fu, S Hu, J Deleo, S Li, C Hopf, J Hoover, S Wang, … - Transplantation, 2002 - journals.lww.com Skip Navigation Links Home > May 15, 2002 - Volume 73 - Issue 9 > Long-term islet graft survival
in streptozotocin- and autoim... ... Fu, Fumin; Hu, Shiling; Deleo, Jeffrey; Li, Shu; Hopf,
Christine; Hoover, Jennifer; Wang, Shuya; Brinkmann, Volker; Lake, Philip; Shi, Victor C. Cited by 33 - Related articles - BL Direct - All 3 versions
[CITATION] FTY720 has no negative impact on human islet function in vitro after exposure for …
W Truong, JA Emamaullee, S Merani, … - American Journal of …, 2007 - Blackwell Publishing Ltd Related articles
S Rutti, JA Ehses, RA Sibler, R Prazak, L Rohrer, S … - Endocrinology, 2009 - Endocrine Soc A low high-density lipoprotein (HDL) plasma concentration and the abundance of small dense
low-density lipoproteins (LDL) are risk factors for developing type 2 diabetes. We therefore investigated
whether HDL and LDL play a role in the regulation of pancreatic islet cell apoptosis, ... Related articles - All 2 versions
