- ►diabetesjournals.org R Gao, J Ustinov, MA Pulkkinen, K Lundin, O Korsgren, … - Diabetes, 2003 - Am Diabetes Assoc We have reproduced a previously described method for the in vitro generation of endocrine cells
in adult human pancreatic tissue culture. The aim of this study was to characterize the nature
of pancreatic progenitor cells and to identify the factors necessary for their differentiation ... Cited by 156 - Related articles - BL Direct - All 7 versions
A Suzuki, H Nakauchi, H Taniguchi - Diabetes, 2004 - Am Diabetes Assoc During pancreatic development, neogenesis, and regeneration, stem cells might act as a central
player to generate endocrine, acinar, and duct cells. Although these cells are well known as
pancreatic stem cells (PSCs), indisputable proof of their existence has not been reported. ... Cited by 138 - Related articles - BL Direct - All 4 versions
S Bonner-Weir, M Taneja, GC Weir, K … - Proceedings of the …, 2000 - National Acad Sciences A major obstacle to successful islet transplantation for both type 1 and 2 diabetes is an inadequate
supply of insulin-producing tissue. This need for transplantable human islets has stimulated efforts
to expand existing pancreatic islets and/or grow new ones. To test the hypothesis that ... Cited by 744 - Related articles - BL Direct - All 10 versions
R Gao, J Ustinov, O Korsgren, T Otonkoski - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The neogenesis of islets from cultured human adult pancreatic tissue
has been reported. The islet progenitors have been thought to be ductal cells. Since previous
experiments have been 'contaminated' by a number of pre-existing islet cells, we ... Cited by 43 - Related articles - BL Direct - All 5 versions
A Lechner, AL Nolan, RA Blacken, JF Habener - Biochemical and Biophysical …, 2005 - Elsevier Cellular replacement therapy holds promise for the treatment of diabetes mellitus but donor tissue
is severely limited. Therefore, we investigated whether insulin-secreting cells could be differentiated
in vitro from a monolayer of cells expanded from human donor pancreatic islets. We ... Cited by 64 - Related articles - All 4 versions
- ►umich.edu [PDF] MK Treutelaar, JM Skidmore, CL Dias-Leme, M Hara, L … - Diabetes, 2003 - Am Diabetes Assoc To clarify the lineage relationship between cells that express the neural stem cell marker nestin
and endocrine cells of the pancreas, we analyzed offspring of a cross between mice carrying
a nestin promoter/enhancer-driven cre-recombinase (Nestin-cre) and C57BL/6J-Gtrosa26 ... Cited by 114 - Related articles - BL Direct - All 5 versions
VK Ramiya, M Maraist, KE Arfors, DA Schatz, AB … - Nature medicine, 2000 - ntbiomol.unibe.ch Islets of Langerhans have a cellular organization ideal for rapid, yet finely controlled, responses
to changes in blood glu- cose levels1–6. During embryogenesis, islet development seems to
be initiated from stem cells associated with the pancreatic ductal epithelium that ... Cited by 614 - Related articles - View as HTML - BL Direct - All 5 versions
H Zulewski, EJ Abraham, MJ Gerlach, PB Daniel, W … - Diabetes, 2001 - Am Diabetes Assoc The endocrine cells of the rat pancreatic islets of Langerhans, including insulin-producing
β-cells, turn over every 40–50 days by processes of apoptosis and the proliferation and differentiation
of new islet cells (neogenesis) from progenitor epithelial cells located in the pancreatic ... Cited by 629 - Related articles - BL Direct - All 7 versions
RM Seaberg, SR Smukler, TJ Kieffer, G Enikolopov, … - Nature Biotechnology, 2004 - utoronto.ca The clonal isolation of putative adult pancreatic precursors has been an elusive goal of researchers
seeking to develop cell replacement strategies for diabetes. We report the clonal identification
of multipotent precursor cells from the adult mouse pancreas. The application of a serum- ... Cited by 263 - Related articles - BL Direct - All 13 versions
MC Gershengorn, AA Hardikar, C Wei, E Geras-Raaka, … - Science, 2004 - sciencemag.org Insulin-expressing beta cells, found in pancreatic islets, are capable of generating more beta
cells even in the adult. We show that fibroblast-like cells derived from adult human islets donated
postmortem proliferate readily in vitro. These mesenchymal-type cells, which exhibit no ... Cited by 188 - Related articles - All 11 versions
