BW Kahan, LM Jacobson, DA Hullett, JM … - Diabetes, 2003 - Am Diabetes Assoc Embryonic stem (ES) cells differentiating in vitro reproduce many facets of
early embryonic development, including the expression of developmentally
regulated transcription factors and the differentiation of multipotent ... Cited by 100 - Related articles - BL Direct - All 6 versions
P Blyszczuk, J Czyz, G Kania, M Wagner, U … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mouse embryonic stem (ES) cells differentiate into cells of all three primary
germ layers including endodermal cells that produce insulin in vitro. We show
that constitutive expression of Pax4 (Pax4 + ), and to a lesser extent Pdx1 ... Cited by 326 - Related articles - BL Direct - All 11 versions
S Sipione, A Eshpeter, JG Lyon, GS Korbutt, … - Diabetologia, 2004 - Springer Aim/hypothesis. Embryonic stem (ES) cells have been proposed as a potential
source of tissue for transplan- tation for the treatment of Type 1 diabetes.
However, studies showing differentiation of beta cells from ES cells are ... Cited by 122 - Related articles - BL Direct - All 6 versions
Y Moritoh, E Yamato, Y Yasui, S Miyazaki, J … - Diabetes, 2003 - Am Diabetes Assoc Embryonic stem (ES) cells can differentiate into many cell types and are
expected to be useful for tissue engineering. Recent reports have shown that ES
cells can differentiate into insulin-producing cells in response to the ... Cited by 123 - Related articles - BL Direct - All 4 versions
Y Hori, IC Rulifson, BC Tsai, JJ Heit, JD … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences The use of embryonic stem cells for cell-replacement therapy in diseases like
diabetes mellitus requires methods to control the development of multipotent
cells. We report that treatment of mouse embryonic stem cells with ... Cited by 342 - Related articles - BL Direct - All 10 versions
- ►colorado.edu [PDF] J Rajagopal, WJ Anderson, S Kume, OI … - Science, 2003 - sciencemag.org Despite antibody staining, we did not detect insulin 1 mRNA by reverse
transcription-polymerase chain reaction (RT-PCR) and insulin 2 mRNA detection
was weak. Multiple primers used during all five stages of the protocol (1) ... Cited by 356 - Related articles - All 5 versions
M Hansson, A Tonning, U Frandsen, A Petri, J … - Diabetes, 2004 - Am Diabetes Assoc Several recent reports claim the generation of insulin-producing cells from
embryonic stem cells via the differentiation of progenitors that express nestin.
Here, we investigate further the properties of these insulin-containing ... Cited by 137 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Miyazaki, E Yamato, J Miyazaki - Diabetes, 2004 - Am Diabetes Assoc Embryonic stem (ES) cells can differentiate into many cell types. Recent reports
have shown that ES cells can differentiate into insulin-producing cells.
However, the differentiation is not efficient enough to produce insulin- ... Cited by 152 - Related articles - BL Direct - All 4 versions
- ►alphamedpress.org A Shiroi, M Yoshikawa, H Yokota, H Fukui, S … - Stem Cells, 2002 - AlphaMed Press Background and Aims. Embryonic stem (ES) cells have a pluripotent ability to
differentiate into a variety of cell lineages in vitro. We have recently
identified the emergence of cellular clusters within differentiated ES cell ... Cited by 147 - Related articles - BL Direct - All 7 versions
- ►imim.cat [PDF] T Leon-Quinto, J Jones, A Skoudy, M Burcin, … - Diabetologia, 2004 - Springer Aims/hypothesis. We recently demonstrated that insu- lin-producing cells derived
from embryonic stem cells normalise hyperglycaemia in transplanted diabetic
mice. The differentiation and selection procedure, however, was successful ... Cited by 117 - Related articles - BL Direct - All 7 versions
