- ►diabetesjournals.org S Srivastava, HJ Goren - Diabetes, 2003 - Am Diabetes Assoc Four hypotheses have been posited on the role of insulin in glucose-stimulated
insulin secretion; available evidence has supported insulin as being 1)
essential, 2) a positive modulator, 3) a negative modulator, or 4) not ... Cited by 19 - Related articles - BL Direct - All 4 versions
WS Zawalich, KC Zawalich - Journal of Biological Chemistry, 2002 - ASBMB Isolated perifused rat islets were stimulated with glucose, exogenous insulin,
or carbachol. C-peptide and, where possible, insulin secretory rates were
measured. Glucose (8-10 mM) induced dose-dependent and kinetically similar ... Cited by 21 - Related articles - BL Direct - All 6 versions
J Westerlund, BA Wolf, P Bergsten - Diabetes, 2002 - Am Diabetes Assoc An insulin-mimetic compound (L-783,281) was used in an attempt to determine the
role of the β-cell insulin receptor (IR) on insulin release. Islets were
isolated from C57Bl/6j mice and cultured for 1 to 4 days. Insulin release ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►ncue.edu.tw [PDF] SJ Persaud, H Asare-Anane, PM Jones - FEBS letters, 2002 - Elsevier There is no consensus on the role of insulin secreted from pancreatic β-cells
in regulating its own secretion, either in rodent islets or in human islets. We
have now investigated whether there is an autocrine signalling role for ... Cited by 46 - Related articles - All 7 versions
- ►nih.gov [PDF] J Stagner, E Samols, K Polonsky, W Pugh - Journal of Clinical Investigation, 1986 - pubmedcentral.nih.gov To test whether insulin secretion is self-regulatory, canine pan- creata were
isolated and perfused in vitro and were infused with 0.3, 0.6, or 1.2 mU/ml
exogenous insulin. Basaland arginine- stimulated concentrations of ... Cited by 18 - Related articles - All 7 versions
- ►endocrinology-journals.org [PDF] WS Zawalich, GJ Tesz, KC Zawalich - Journal of Endocrinology, 2002 - Soc Endocrinology We examined the effects of phosphatidylinositol 3-kinase (PI3K) inhibition by
wortmannin or LY294002 on glucose-induced secretion from mouse islets. Islets
were collagenase isolated and perifused or subjected to Western blot ... Cited by 28 - Related articles - BL Direct - All 6 versions
GG Xu, ZY Gao, PD Borge Jr, PA Jegier, RA … - Biochemistry, 2000 - ncbi.nlm.nih.gov The insulin receptor signaling pathway is present in beta-cells and is believed
to be important in beta-cell function. We show here that insulin directly
regulates beta-cell function in isolated rodent islets. Long-term insulin ... Cited by 41 - Related articles - BL Direct - All 3 versions
CA Aspinwall, L Huang, JRT Lakey, RT … - Anal. Chem, 1999 - pubs.acs.org Two methods for amperometric detection of exocytosis at single pancreatic
β-cells were compared. In the first, direct detection of insulin was
accomplished using an insulin-sensitive chemically modified electrode. In ... Cited by 29 - Related articles - BL Direct - All 3 versions
MJ Dunne - Diabetic Medicine, 2000 - ingentaconnect.com In 1968, reports of the ®rst microelectrode recordings of insulin-secreting
cells were published. Thirty years later it is now established that electrical
responses of b-cells play a critical role in stimulus-secretion coupling. ... Cited by 5 - Related articles - All 4 versions
K Eto, T Yamashita, Y Tsubamoto, Y Terauchi, … - Diabetes, 2002 - Am Diabetes Assoc The role of phosphatidylinositol (PI) 3-kinase in the regulation of pancreatic
ß-cell function was investigated. PI 3-kinase activity in p85 regulatory
subunit–deficient (p85 -/- ) islets was decreased to 20% of that in ... Cited by 42 - Related articles - BL Direct - All 5 versions
