S Winzell… - Diabetes, 2003 - Am Diabetes Assoc Lipid perturbations associated with triglyceride overstorage in β-cells impair
insulin secretion, a process termed lipotoxicity. To assess the role of
hormone-sensitive lipase, which is expressed and enzymatically active in β- ... Cited by 52 - Related articles - BL Direct - All 4 versions
H Lindvall, P Nevsten, K Ström, R Wallenberg … - Journal of Biological Chemistry, 2004 - ASBMB Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization in
many cell types. Two isoforms of HSL are known to date, namely HSL adi (84 kDa
in rat) and HSL tes (130 kDa in rat). These are encoded by the same gene, ... Cited by 22 - Related articles - BL Direct - All 4 versions
H Mulder, M Sörhede-Winzell, JA Contreras, M … - Journal of Biological Chemistry, 2003 - ASBMB Lipid metabolism plays an important role in glucose homeostasis under normal and
pathological conditions. In adipocytes, skeletal muscle, and pancreatic
β-cells, lipids are mobilized from acylglycerides by the hormone-sensitive ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org MS Winzell, H Svensson, P Arner, B Ahrén, C … - Diabetes, 2001 - Am Diabetes Assoc Hormone-sensitive lipase (HSL) is expressed and enzymatically active in β-cells
and has been proposed to be involved in the generation of the lipid-derived
signal that seems to be necessary for glucose-stimulated insulin secretion. ... Cited by 38 - Related articles - BL Direct - All 5 versions
H Mulder, S Yang, MS Winzell, C Holm, B … - Diabetes, 2004 - Am Diabetes Assoc Lipids may serve as coupling factors in K ATP -independent glucose sensing in
β-cells. We have previously demonstrated that β-cells harbor lipase
activities, one of which is the hormone-sensitive lipase. Whether β-cell ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Roduit, P Masiello, SP Wang, H Li, GA … - Diabetes, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the
β-cell adapts its secretory capacity in obesity and diabetes. In addition,
hormone-sensitive lipase (HSL) is expressed in β-cells and may provide ... Cited by 74 - Related articles - BL Direct - All 5 versions
- ►endojournals.org T Yamashita, K Eto, Y Okazaki, S Yamashita, … - Endocrinology, 2004 - Endocrine Soc Triglyceride (TG) accumulation in pancreatic ß-cells is thought to be
associated with impaired insulin secretory response to glucose (lipotoxicity).
To better understand the mechanism of the impaired insulin secretory ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►endojournals.org V Poitout - Endocrinology, 2004 - Endocrine Soc The metabolic syndrome associates central adiposity, insulin resistance,
hypertension, and dyslipidemia, and represents a high-risk factor for
cardiovascular disease and type 2 diabetes. The lipotoxicity hypothesis ... Cited by 15 - Related articles - BL Direct - All 2 versions
MS Winzell, C Holm, B Ahrén - Biochemical and Biophysical Research …, 2003 - Elsevier Lipid accumulation in pancreatic β-cells during high-fat (HF) feeding may be
involved in inducing a defective insulin secretion due to lipotoxicity.
Hormone-sensitive lipase (HSL) is expressed and active in β-cells, but its ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] H Mulder, LS Holst, H Svensson, E Degerman … - Diabetes, 1999 - Am Diabetes Assoc Triglycerides in the -cell may be important for stim- ulus-secretion coupling,
through provision of a lipid- derived signal, and for pathogenetic events in
NIDDM, where lipids may adversely affect -cell function. In adipose ... Cited by 87 - Related articles - BL Direct - All 4 versions
