B Raju, VP McGregor, PE Cryer - Diabetes, 2003 - Am Diabetes Assoc The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent
antecedent iatrogenic hypoglycemia causes both defective glucose counterregulation (by reducing
the epinephrine response in the setting of an absent glucagon response) and ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►physiology.org VP McGregor, S Banarer, PE Cryer - American Journal of …, 2002 - Am Physiological Soc We tested the hypothesis that increased endogenous cortisol secretion reduces autonomic neuroendocrine
and neurogenic symptom responses to subsequent hypoglycemia. Twelve healthy young adults
were studied on two separate occasions, once after infusions of a pharmacological dose ... Cited by 31 - Related articles - BL Direct - All 5 versions
PA Goldberg, R Weiss, RJ McCrimmon, EV Hintz, JD … - Diabetes, 2006 - Am Diabetes Assoc Hypoglycemia-associated autonomic failure (HAAF) occurs commonly in patients with longstanding
diabetes, placing affected patients at increased risk for severe hypoglycemia. Previous studies
have suggested that hypoglycemia-induced hypercortisolemia may be responsible for ... Cited by 11 - Related articles - BL Direct - All 6 versions
DA Sandoval, L Ping, AR Neill, S Morrey, SN Davis - Diabetes, 2003 - Am Diabetes Assoc Physiological levels of cortisol have been found to blunt neuroendocrine and metabolic responses
to subsequent hypoglycemia in humans. The aim of this study was to determine whether cortisol
acts directly on the brain to elicit this effect. A total of 41 conscious unrestrained Sprague- ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DE Flanagan, T Keshavarz, ML Evans, S Flanagan, X … - Diabetes, 2003 - Am Diabetes Assoc We have explored the role of individual elements of the hypothalamic pituitary adrenal axis on
the pathogenesis of hypoglycemia-associated autonomic failure. Five groups of male
Sprague-Dawley rats were used. Control animals had 3 days of sham treatment followed ... Cited by 39 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] SN Davis, C Shavers, B Davis, F … - Journal of Clinical …, 1997 - pubmedcentral.nih.gov The aim of this study was to determine whether preventing increases in plasma cortisol during
antecedent hypoglyce- mia preserves autonomic nervous system counterregulatory responses
during subsequent hypoglycemia. Experiments were carried out on 15 (8 male/7 female) ... Cited by 73 - Related articles - BL Direct - All 6 versions
- ►physiology.org K Shum, K Inouye, O Chan, J Mathoo, D … - American Journal of …, 2001 - Am Physiological Soc This study aimed to differentiate the effects of repeated antecedent hypoglycemia, antecedent
marked hyperinsulinemia, and antecedent increases in corticosterone on counterregulation to
subsequent hypoglycemia in normal rats. Specifically, we examined whether exposure to ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org VP McGregor, JS Greiwe, S Banarer, PE Cryer - Diabetes, 2002 - Am Diabetes Assoc Hypoglycemia-associated autonomic failure (HAAF)—reduced autonomic (including adrenomedullary
epinephrine) and symptomatic responses to hypoglycemia caused by recent antecedent
hypoglycemia—plays a key role in the pathogenesis of defective glucose ... Cited by 26 - Related articles - BL Direct - All 8 versions
- ►physiology.org KE Inouye, O Chan, JTY Yue, SG … - American Journal of …, 2005 - Am Physiological Soc Epinephrine, norepinephrine, and corticosterone responses to hypoglycemia are impaired in
diabetic rats. Recurrent hypoglycemia further diminishes epinephrine responses. This study
examined the sympathoadrenal system and hypothalamo-pituitary-adrenal axis for ... Cited by 14 - Related articles - All 4 versions
- ►physiology.org SB Evans, CW Wilkinson, K Bentson, P … - American Journal of …, 2001 - Am Physiological Soc The mechanism(s) underlying hypoglycemia-associated autonomic failure (HAAF) are
unknown. To test the hypothesis that the activation of brain regions involved in the counterregulatory
response to hypoglycemia is blunted with HAAF, rats were studied in a 2-day protocol. ... Cited by 47 - Related articles - BL Direct - All 4 versions
