H Kim, T Sasaki, K Maeda, D Koya, A … - Diabetes, 2003 - Am Diabetes Assoc Streptozocin (STZ)-induced diabetic rats show hyperalgesia that is partially
attributed to altered protein kinase C (PKC) activity. Both attenuated neuronal
nitric oxide synthase (nNOS)-cGMP system and tetrodotoxin-resistant (TTX-R) ... Cited by 35 - Related articles - BL Direct - All 4 versions
SI Yamagishi, K Uehara, S Otsuki, S … - Journal of neurochemistry, 2003 - interscience.wiley.com To explore the relationship between polyol pathway and protein kinase C (PKC),
we examined PKC activities and expressions of PKC isoforms separately in
endoneurial and vessel-rich epineurial tissues in diabetic mice transgenic ... Cited by 25 - Related articles - BL Direct - All 4 versions
T Sasase, H Yamada, K Sakoda, N Imagawa, T … - Diabetes Obes. Metab, 2005 - interscience.wiley.com Aim: Activation of protein kinase C (PKC) is thought to play an important role
in the pathogenesis of diabetic microvascular complications. PKC-β is elevated
in hyperglycaemic conditions, both in vivo and in vitro. In this study, ... Cited by 8 - Related articles - BL Direct - All 4 versions
J Nakamura, K Kato, Y Hamada, M Nakayama, … - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Increased protein kinase C (PKC) activity has been implicated in the
pathogenesis of diabetic retinopathy and nephropathy. However, the role of PKC
in diabetic neuropathy remains unclear. The present study was conducted to ... Cited by 142 - Related articles - BL Direct - All 4 versions
F Hayase, H Matsuura, M Sanada, K Kitada- … - Neuroscience letters, 2007 - Elsevier Experimental evidence has been presented to suggest that protein kinase Cβ
isoform-selective inhibitor LY333531 is effective at alleviating diabetic
hyperalgesia. In the present study, we isolated small (≤25 μm in soma ... Cited by 5 - Related articles - All 3 versions
AI Vinik, V Bril, P Kempler, WJ Litchy, S … - Clinical therapeutics, 2005 - Elsevier Patients were enrolled in a multinational, randomized, Phase II, double-blind,
placebo-controlled parallel-group trial comparing 32 mg/d or 64 mg/d RBX with
placebo for 1 year. DPN was identified by abnormal measurable vibration ... Cited by 44 - Related articles - All 3 versions
MA Cotter, AM Jack, NE Cameron - Clinical Science, 2002 - cs.portlandpress.com Elevated protein kinase C activity has been linked to the vascular and neural
complications of diabetes. The aim of the present study was to examine the
involvement of the b-isoform of protein kinase C in abnormalities of ... Cited by 59 - Related articles - Cached - BL Direct - All 13 versions
M Ohsawa, J Kamei - European journal of pharmacology, 1999 - Elsevier We examined the tail-flick response to various heat intensities in diabetic and
non-diabetic mice. Heat intensities were set to one of five values by adjusting
the source voltage of a 50-W projection bulb to 25, 35, 50, 65 and 80 V. ... Cited by 42 - Related articles - All 5 versions
K Uehara, SI Yamagishi, S Otsuki, S Chin, S … - Diabetes, 2004 - Am Diabetes Assoc We explored the specific impact of polyol pathway hyperactivity on dorsal root
ganglia (DRG) using transgenic mice that overexpress human aldose reductase
because DRG changes are crucial for the development of diabetic sensory ... Cited by 19 - Related articles - BL Direct - All 4 versions
