- ►diabetesjournals.org SH Kim, X Ma, T Klupa, C Powers, M Pezzolesi, JH … - Diabetes, 2003 - Am Diabetes Assoc Mutations in hepatocyte nuclear factor (HNF)-1 (MODY3) account for the largest proportion of
maturity-onset diabetes of the young (MODY) cases in the US This form of diabetes is characterized
by impaired insulin secretion in ... Cited by 22 - Related articles - BL Direct - All 3 versions
SH Kim, X Ma, T Klupa, C Powers, M Pezzolesi, JH … - Diabetes, 2003 - Am Diabetes Assoc Page 1. Brief Genetics Report Genetic Modifiers of the Age at Diagnosis of Diabetes (MODY3) in Carriers
of Hepatocyte Nuclear Factor-1 Mutations Map to Chromosomes 5p15, 9q22, and 14q24 Sung-Hoon Kim,
1,2 Xiaowei Ma, 1,2 Tomasz Klupa, 1,2 Christine Powers, 1 Marcus Pezzolesi, 1 ... Cited by 2 - Related articles
TM Frayling, S Wiltshire, GA Hitman, M Walker, JC Levy … - Diabetes, 2003 - Am Diabetes Assoc A young onset of type 2 diabetes is likely to result, in part, from greater genetic susceptibility.
Young-onset families may therefore represent a group in which genes are more easily detectable by
linkage. To test this hypothesis, ... Cited by 29 - Related articles - BL Direct - All 5 versions
MG Pezzolesi, M Nam, T Nagase, T Klupa, JS Dunn, … - Diabetes, 2004 - Am Diabetes Assoc In a panel of large Caucasian pedigrees, we genotyped markers in eight chromosomal regions
previously reported as supporting linkage with type 2 diabetes. We previously reported significant
linkage on chromosome 20q (maximum ... Cited by 15 - Related articles - BL Direct - All 4 versions
F Thameem, X Yang, PA Permana, JK Wolford, C … - Human genetics, 2003 - Springer Abstract Elevation of plasma glucose concentration may induce generation of oxygen-free radicals,
which can play an important role in the progression of diabetes and/or de- velopment of its
complications. Various glutathione ... Cited by 4 - Related articles - BL Direct - All 4 versions
Z Ma, A Daquin, J Yao, D Rodgers, MW Thompson, … - Archives of Biochemistry …, 2003 - Elsevier The puromycin-sensitive aminopeptidase was found to be resistant to proteolysis by trypsin,
chymotrypsin, and protease V8 but was cleaved into an N-terminal 60-kDa fragment and a C-terminal
33-kDa fragment by proteinase K. ... Cited by 5 - Related articles - All 4 versions
SH Kim, X Ma, S Weremowicz, T Ercolino, C Powers, W … - Diabetes, 2004 - Am Diabetes Assoc Maturity-onset diabetes of the young (MODY) is a subtype of diabetes defined by an autosomal
dominant inheritance and a young onset. Six MODY genes have been discovered to date. To identify
additional MODY loci, we conducted ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org T Klupa, JH Warram, A Antonellis, M Pezzolesi, M … - Diabetes Care, 2002 - Am Diabetes Assoc RESULTS—HNF-1α mutations cosegregated with diabetes in only 13 families, all with a mean age at
onset <35 years. Insulin secretion was diminished or absent in mutation carriers (n = 101), and
diabetes developed in 65% by age 25 ... Cited by 37 - Related articles - BL Direct - All 5 versions
