- ►whitelabs.org [PDF] AM Valverde, DJ Burks, I Fabregat, TL Fisher, … - Diabetes, 2003 - Am Diabetes Assoc To assess the role of insulin receptor (IR) substrate (IRS)-2 in insulin action
and resistance in the liver, immortalized neonatal hepatocyte cell lines have
been generated from IRS-2 −/− , IRS-2 +/− , and wild-type mice. These ... Cited by 56 - Related articles - BL Direct - All 7 versions
I Fabregat, M Lorenzo, M Benito - Biochemical and Biophysical Research …, 1989 - Elsevier Rat foetal hepatocytes in primary cultures were used as a model for the study of
malic enzyme gene expression. Carbohydrates and glycolytic metabolites produced
the precocious induction of the malic enzyme in foetal hepatocytes cultured ... Cited by 14 - Related articles - All 3 versions
- ►endojournals.org MP Sajan, ML Standaert, A Miura, CR Kahn, … - Molecular Endocrinology, 2004 - Endocrine Soc Insulin receptor substrates (IRSs) 1 and 2 are postulated to control the
activation of phosphatidylinositol 3-kinase (PI3K)-dependent signaling factors,
namely, atypical protein kinase C (aPKC) and protein kinase B (PKB)/Akt, ... Cited by 11 - Related articles - BL Direct - All 4 versions
AM Valverde, I Fabregat, DJ Burks, MF White, … - Hepatology, 2004 - interscience.wiley.com To assess the role of insulin action and inaction in the liver, immortalized
hepatocyte cell lines have been generated from insulin receptor substrate
(IRS)-2 -/- and wild-type mice. Using this model, we have recently ... Cited by 22 - Related articles - All 3 versions
ML Standaert, MP Sajan, A Miura, Y Kanoh, … - Journal of Biological Chemistry, 2004 - ASBMB Insulin resistance in type 2 diabetes is characterized by defects in muscle
glucose uptake and hepatic overproduction of both glucose and lipids. These
hepatic defects are perplexing because insulin normally suppresses glucose ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►nih.gov M Matsumoto, W Ogawa, K Akimoto, H Inoue, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig PKCλ is implicated as a downstream effector of PI3K in insulin action. We show
here that mice that lack PKCλ specifically in the liver (L-λKO mice), produced
with the use of the Cre-loxP system, exhibit increased insulin sensitivity ... Cited by 74 - Related articles - BL Direct - All 11 versions
- ►nih.gov K Ueki, T Yamauchi, H Tamemoto, K Tobe, R … - Journal of Clinical Investigation, 2000 - Am Soc Clin Investig Insulin resistance is commonly observed both in overt diabetes and in
individuals prone to, but not yet manifesting, diabetes. Hence the maintenance
or restoration of insulin sensitivity may prevent the onset of this ... Cited by 37 - Related articles - BL Direct - All 5 versions
R Suzuki, K Tobe, M Aoyama, A Inoue, K … - Journal of Biological Chemistry, 2004 - ASBMB We previously reported that insulin receptor substrate-2 (IRS-2)-deficient mice
develop diabetes as a result of insulin resistance in the liver and failure of
-cell hyperplasia. In this study we introduced the IRS-2 gene specifically ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►nih.gov X Dong, S Park, X Lin, K Copps, X Yi, MF … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF
receptor signals with heterologous pathways to coordinate growth and metabolism.
Since Irs2 is thought to be especially important in hepatic nutrient ... Cited by 36 - Related articles - BL Direct - All 12 versions
A Mora, C Lipina, F Tronche, C Sutherland, … - Biochemical Journal, 2005 - pubmedcentral.nih.gov The liver plays an important role in insulin-regulated glucose homoeostasis. To
study the function of the PDK1 (3-phosphoinositide-dependent protein kinase-1)
signalling pathway in mediating insulin's actions in the liver, we employed ... Cited by 31 - Related articles - All 10 versions
