AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass.
In contrast, obese humans with type 2 diabetes have an ∼60% deficit in β-cell
mass. Recent studies in rodents reveal that β-cell mass is regulated, ... Cited by 145 - Related articles - BL Direct - All 6 versions
RA Ritzel, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by a relative β-cell deficit as a result of
increased β-cell apoptosis and islet amyloid derived from the β-cell peptide
islet amyloid polypeptide (IAPP). Human IAPP (h-IAPP) but not mouse IAPP ... Cited by 73 - Related articles - BL Direct - All 9 versions
AE Butler, J Jang, T Gurlo, MD Carty, WC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass,
increased β-cell apoptosis, and impaired insulin secretion. Also, islets in
type 2 diabetes often contain deposits of islet amyloid derived from islet ... Cited by 92 - Related articles - BL Direct - All 9 versions
J Janson, RH Ashley, D Harrison, S McIntyre, … - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc NIDDM is characterized by islet amyloid deposits and decreased -cell mass. Islet
amyloid is derived from the locally expressed protein islet amyloid polypeptide
(IAPP). While it is now widely accepted that abnormal aggregation of IAPP ... Cited by 227 - Related articles - BL Direct - All 7 versions
- ►pnas.org [PDF] J Janson, WC Soeller, PC Roche, RT Nelson, … - Proceedings of the National Academy of Sciences, 1996 - National Acad Sciences Proc. Natl. Acad. Sci. USA Vol. 93, pp. 7283-7288, July 1996 Medical Sciences ... Spontaneous diabetes mellitus in transgenic mice expressing human islet
amyloid polypeptide ... JULIETrE JANSON*, WALTER C. SOELLERt, PATRICK C. ... Cited by 135 - Related articles - BL Direct - All 11 versions
AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing -cell mass.
In contrast, obese humans with type 2 diabetes have an 60% deficit in -cell
mass. Re- cent studies in rodents reveal that -cell mass is regulat- ed, ... Cited by 19 - Related articles - All 2 versions
M Couce, LA Kane, TD O'Brien, J Charlesworth … - Diabetes, 1996 - Am Diabetes Assoc Islet amyloid derived from islet amyloid polypeptide (IAPP) is a well-recognized
feature of type II diabetes. However, the mechanism of islet amyloidogenesis is
unknown. In vitro studies suggest that amino acid residues 20-29 in human, ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] WC Soeller, J Janson, SE Hart, JC Parker, MD … - Diabetes, 1998 - Am Diabetes Assoc We have previously shown that hemizygous transgenic mice expressing human islet
amyloid polypeptide (hIAPP) in pancreatic -cells have no diabetic pheno- type,
whereas in the homozygous state, they developed severe, early-onset ... Cited by 94 - Related articles - BL Direct - All 6 versions
AE Butler, J Janson, S Bonner-Weir, R Ritzel, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by impaired insulin secretion. Some but not all
studies suggest that a decrease in β-cell mass contributes to this. We examined
pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m 2 ; 41 ... Cited by 950 - Related articles - BL Direct - All 4 versions
- ►pnas.org [PDF] CB Verchere, DA D'Alessio, RD Palmiter, GC … - Proceedings of the National Academy of Sciences, 1996 - National Acad Sciences Page 1. Proc. Natl. Acad. Sci. USA Vol. 93, pp. 3492-3496, April 1996 Medical Sciences
Islet amyloid formation associated with hyperglycemia in ... Cited by 134 - Related articles - All 8 versions
