RG Bennett, FG Hamel, WC Duckworth - Diabetes, 2003 - Am Diabetes Assoc Amylin (islet amyloid polypeptide) is the chief component of the islet amyloid
found in type 2 diabetes, and amylin fibril precursors may be cytotoxic to
pancreatic β-cells. Little is known about the prevention of amylin ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JC Florez, S Wiltshire, CM Agapakis, NP Burtt … - Diabetes, 2006 - Am Diabetes Assoc The insulin-degrading enzyme is responsible for the intracellular proteolysis of
insulin. Its gene IDE is located on chromosome 10, in an area with suggestive
linkage to type 2 diabetes and related phenotypes. Due to the impact of ... Cited by 29 - Related articles - BL Direct - All 7 versions
- ►endojournals.org FG Hamel, JL Upward, RG Bennett - Endocrinology, 2003 - Endocrine Soc Insulin-degrading enzyme is responsible for initiating insulin degradation in
cells, but little is known about the factors controlling its activity. Because
obesity and high levels of free fatty acids decrease insulin clearance, we ... Cited by 27 - Related articles - BL Direct - All 5 versions
CJ Groves, S Wiltshire, D Smedley, KR Owen, … - Diabetes, 2003 - Am Diabetes Assoc The gene for insulin-degrading enzyme (IDE) represents a strong positional and
biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome
10q23.3, a region linked to diabetes in several populations; the rat ... Cited by 40 - Related articles - BL Direct - All 4 versions
ES Song, MA Juliano, L Juliano, MG Fried, … - Journal of Biological Chemistry, 2004 - ASBMB It has been reported previously that ATP inhibits the insulysin reaction
(Camberos, MC, Perez, AA, Udrisar, DP, Wanderley, MI, and Cresto, JC (2001) Exp.
Biol. Med. 226, 334–341). We report here that with ... Cited by 20 - Related articles - All 4 versions
- ►utexas.edu [PDF] S Karamohamed, S Demissie, J Volcjak, C Liu … - Diabetes, 2003 - Am Diabetes Assoc Linkage studies have mapped a susceptibility gene for type 2 diabetes to the
long arm of chromosome 10, where we have previously identified a quantitative
trait locus that affects fasting blood glucose within the Framingham Heart ... Cited by 56 - Related articles - BL Direct - All 5 versions
H Shinall, ES Song, LB Hersh - Biochemistry, 2005 - pubs.acs.org Insulysin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation
with hydrogen peroxide, an iron−ascorbate oxidation system, and by treatment
with 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). In each case ... Cited by 36 - Related articles - All 4 versions
HF Gu, S Efendic, S Nordman, CG Östenson, K … - Diabetes, 2004 - Am Diabetes Assoc Insulin-degrading enzyme (IDE) plays a principal role in the proteolysis of
several peptides in addition to insulin and is encoded by IDE, which resides in
a region of chromosome 10q that is linked to type 2 diabetes. Two recent ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►ebmonline.org MC Camberos, AA Perez, DP Udrisar, MI … - Experimental Biology and Medicine, 2001 - SEBM We studied the ability of ATP to inhibit in vitro the degrading activity of
insulin-degrading enzyme. The enzyme was purified from rat skeletal muscle by
successive chromatographic steps. The last purification step showed two ... Cited by 26 - Related articles - BL Direct - All 2 versions
T Saric, D Müller, HJ Seitz, K Pavelic - Molecular and cellular endocrinology, 2003 - Elsevier Insulin-degrading enzyme (IDE) is a metalloprotease implicated in insulin
degradation and suggested to have a variety of additional functions, including
the clearance of amyloid β peptides of Alzheimer's disease. Little is ... Cited by 17 - Related articles - All 5 versions
