EH Koh, MS Kim, JY Park, HS Kim, JY Youn, … - Diabetes, 2003 - Am Diabetes Assoc Lipid accumulation in nonadipose tissues is closely related to the development
of type 2 diabetes in obese subjects. We examined the potential preventive
effect of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ ... Cited by 103 - Related articles - BL Direct - All 6 versions
EH Koh, MS Kim, JY Park, HS Kim, JY Youn, … - Diabetes 2003; 52: 2331 - Am Diabetes Assoc Lipid accumulation in nonadipose tissues is closely related to the development
of type 2 diabetes in obese subjects. We examined the potential preventive
effect of peroxisome proliferator–activated receptor (PPAR)- and PPAR- ... Cited by 1 - Related articles
- ►diabetesjournals.org H Kim, M Haluzik, Z Asghar, D Yau, JW … - Diabetes, 2003 - Am Diabetes Assoc Abnormalities in insulin action are the characteristics of type 2 diabetes.
Dominant-negative muscle-specific IGF-I receptor (MKR) mice exhibit elevated
lipid levels at an early age and eventually develop type 2 diabetes. To ... Cited by 110 - Related articles - BL Direct - All 4 versions
- ►jlr.org K Tordjman, KN Standley, C Bernal-Mizrachi … - The Journal of Lipid Research, 2002 - ASBMB Fatty acids may promote type 2 diabetes by altering insulin secretion from
pancreatic ß cells, a process known as lipotoxicity. The underlying mechanisms
are poorly understood. To test the hypothesis that peroxisome proliferator- ... Cited by 67 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] MJ Holness, ND Smith, GK Greenwood, MC … - Journal of Endocrinology, 2003 - Soc Endocrinology Abnormal depletion or accumulation of islet lipid may be important for the
development of pancreatic cell failure. Long-term lipid sensing by cells may be
co-ordinated via peroxisome proliferator-activated receptors (PPARs). We ... Cited by 27 - Related articles - BL Direct - All 5 versions
- ►nih.gov YT Zhou, M Shimabukuro, MY Wang, Y Lee, M … - Proceedings of the National Academy of Sciences of …, 1998 - National Acad Sciences Expression of peroxisome proliferator-activated receptor α (PPARα) and enzymes
of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional
islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with ... Cited by 134 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org F Lalloyer, B Vandewalle, F Percevault, G … - Diabetes, 2006 - Am Diabetes Assoc Peroxisome proliferator–activated receptor (PPAR) α is a transcription factor
controlling lipid and glucose homeostasis. PPARα-deficient (−/−) mice are
protected from high-fat diet–induced insulin resistance. However, the ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►psu.edu [PDF] M Guerre-Millo, C Rouault, P Poulain, J André … - Diabetes, 2001 - Am Diabetes Assoc Peroxisome proliferator–activated receptor (PPAR)-α controls the expression
of genes involved in lipid metabolism. PPAR-α furthermore participates to
maintain blood glucose during acute metabolic stress, as shown in ... Cited by 135 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org MC Sugden, MJ Holness - Diabetes, 2004 - Am Diabetes Assoc In this review, we discuss the influence of peroxisome proliferator-activated
receptor (PPAR)-α on islet insulin secretion and develop the hypothesis that
modulation of PPAR-α function may be important for the regulation of ... Cited by 33 - Related articles - BL Direct - All 5 versions
HJ Lee, SS Choi, MK Park, YJ An, SY Seo, … - Biochemical and biophysical research communications, 2002 - Elsevier The effect of peroxisome proliferator-activated receptor (PPAR)-α activators on
the liver is well established, but the other effects on muscle and adipose
tissue about lipid metabolism and insulin sensitivity are not clear. We ... Cited by 78 - Related articles - BL Direct - All 6 versions
