- ►diabetesjournals.org C Cheng, DW Zochodne - Diabetes, 2003 - Am Diabetes Assoc Long-term experimental diabetes may best model the prominent and irreversible
sensory deficits of chronic human diabetic polyneuropathy. Whereas irretrievable
loss of sensory neurons, if present, would be an unfortunate feature of the ... Cited by 78 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AM Schmeichel, JD Schmelzer, PA Low - Diabetes, 2003 - Am Diabetes Assoc We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion
(DRG) neurons using immunohistochemical and electrophysiologic techniques for
evidence of oxidative injury. Experimental diabetic neuropathy was induced ... Cited by 146 - Related articles - BL Direct - All 10 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic
neuropathy, but the mechanisms remain unidentified. Here we provide evidence
that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector ... Cited by 87 - Related articles - BL Direct - All 10 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ... Cited by 38 - Related articles - BL Direct - All 11 versions
JW Russell, KA Sullivan, AJ Windebank, DN … - Neurobiology of disease, 1999 - Elsevier Recent clinical trials indicate that the severity of diabetic neuropathy is
correlated with the level of patient glycemic control. In the current study,
hyperglycemia induces apoptotic changes in dorsal root ganglion neurons and ... Cited by 177 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org DW Zochodne, VMK Verge, C Cheng, H Sun, … - Brain, 2001 - Oxford Univ Press Targeting of dorsal root ganglia by diabetes could account for the selective
sensory abnormalities that patients with early diabetic polyneuropathy develop.
In this work, we addressed survival, phenotype and gene expression in ... Cited by 55 - Related articles - BL Direct - All 5 versions
NE Cameron, Z Tuck, L McCabe, MA Cotter - Diabetologia, 2001 - Springer Page 1. Oxidative stress contributes to the neural and vascu- lar complications
of diabetes [1, 2]. For nerve, antiox- idant protection ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►nih.gov O Ilnytska, VV Lyzogubov, MJ Stevens, VR … - Diabetes, 2006 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental
mechanism in the pathogenesis of diabetes complications including diabetic
neuropathy. This study evaluated the role of PARP in diabetic sensory ... Cited by 26 - Related articles - BL Direct - All 10 versions
- ►nih.gov IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the
pathogenesis of diabetes complications, is considered a downstream effector of
oxidative-nitrosative stress. However, some recent findings suggest that it ... Cited by 36 - Related articles - BL Direct - All 11 versions
