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Scholar Results 1 - 10 of about 101 related to Sayers: Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory.... (0.10 sec) 

Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory …


NM Sayers, LJ Beswick, A Middlemas, NA … - Diabetes, 2003 - Am Diabetes Assoc
The relation between neurofilament expression and/or phosphorylation in the
proximal versus distal components of the sensory peripheral neuraxis was studied
and related to disorders in structure and function of the distal axon of ...
Cited by 30 - Related articles - BL Direct - All 6 versions

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of …

- diabetesjournals.org
TJ Huang, SA Price, L Chilton, NA Calcutt, … - Diabetes, 2003 - Am Diabetes Assoc
Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration
in diabetes complications. The aim of this study was to determine whether
deficits in insulin-dependent neurotrophic support contributed to ...
Cited by 55 - Related articles - BL Direct - All 5 versions

Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats.


AP Mizisin, NA Calcutt, DR Tomlinson, A … - Journal of the peripheral nervous system: JPNS, 1999 - ncbi.nlm.nih.gov
The ability of neurotrophin-3 (NT-3) to reverse established nerve disorders was
investigated in the peripheral neuraxis of streptozotocin-diabetic rats. Sciatic
sensory and motor nerve conduction velocity deficits established after 2 ...
Cited by 34 - Related articles - BL Direct - All 2 versions

Enhanced activation of axonally transported stress-activated protein kinases in peripheral …

- oxfordjournals.org
A Middlemas, JD Delcroix, NM Sayers, DR … - Brain, 2003 - Oxford Univ Press
The objective was to determine whether stress-activated protein kinases (SAPKs)
mediated the transfer of diabetes-induced stress signals from the periphery to
somata of sensory neurons. Thus, we characterized axonal transport of SAPKs ...
Cited by 37 - Related articles - All 7 versions

Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy

- diabetesjournals.org
M Kishi, J Tanabe, JD Schmelzer, PA Low - Diabetes, 2002 - Am Diabetes Assoc
Chronic hyperglycemia results in a predominantly sensory neuropathy. Recent
studies suggest that dorsal root ganglion (DRG) neurons comprise a specific
target and may be responsible for the important complication of diabetic ...
Cited by 38 - Related articles - BL Direct - All 4 versions

Neurofilaments in diabetic neuropathy.


P Fernyhough, RE Schmidt - International review of neurobiology, 2002 - ncbi.nlm.nih.gov
This review discusses the role of abnormal neurofilament (NF) expression,
processing, and structure as an etiological factor in diabetic neuropathy.
Diabetic sensory and autonomic neuropathy in humans is associated with a ...
Cited by 16 - Related articles - BL Direct

Does diabetes target ganglion neurones?: Progressive sensory neurone involvement in long …

- oxfordjournals.org
DW Zochodne, VMK Verge, C Cheng, H Sun, … - Brain, 2001 - Oxford Univ Press
Targeting of dorsal root ganglia by diabetes could account for the selective
sensory abnormalities that patients with early diabetic polyneuropathy develop.
In this work, we addressed survival, phenotype and gene expression in ...
Cited by 55 - Related articles - BL Direct - All 5 versions

Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord


K Sugimoto, Y Murakawa, AAF Sima - Journal of the Peripheral Nervous System, 2002 - interscience.wiley.com
Abstract The expression and localization of the insulin receptor (IR) was
examined in rat dorsal root ganglia (DRG) and spinal cord using Western
blotting, in situ hybridization and immunocytochemistry. Western blotting ...
Cited by 47 - Related articles - BL Direct - All 3 versions

Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic …


AAF Sima, W Zhang, ZG Li, Y Murakawa, CR … - Diabetes, 2004 - Am Diabetes Assoc
To explore the molecular abnormalities underlying the degeneration of the node
of Ranvier, a characteristic aberration of type 1 diabetic neuropathy, we
examined in type 1 BB/Wor and type 2 BBZDR/Wor rats changes in expression ...
Cited by 40 - Related articles - BL Direct - All 4 versions

Neurofilament and tubulin gene expression in progressive experimental diabetes: failure of …

- oxfordjournals.org
JN Scott, AW Clark, DW Zochodne - Brain, 1999 - Oxford Univ Press
In human and experimental diabetes, the relationship between molecular
abnormalities in perikarya of sensory neurons and structural abnormalities in
their distal axons is largely unexplored. In this study we examined ...
Cited by 64 - Related articles - BL Direct - All 4 versions


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