- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S Ellard, … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and catalyzes the
rate-limiting step for β-cell glucose metabolism. We report two novel GCK mutations (T65I and
W99R) that have arisen de novo in two families with familial hypoglycemia. Insulin levels, ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org AL Cuesta-Muñoz, H Huopio, T Otonkoski, JM Gomez- … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor in the pancreatic
β-cell, where it governs glucose-stimulated insulin secretion (GSIS). Heterozygous inactivating
mutations in the glucokinase gene (GCK) cause a mild form of diabetes (maturity-onset ... Cited by 69 - Related articles - BL Direct - All 5 versions
HBT Christesen, BB Jacobsen, S Odili, C Buettger, A … - Diabetes, 2002 - Am Diabetes Assoc In this study, a second case of hyperinsulinemic hypoglycemia due to activation of glucokinase
is reported. The 14-year-old proband had a history of neonatal hypoglycemia, treated with
diazoxide. He was admitted with coma and convulsions due to nonketotic hypoglycemia. ... Cited by 118 - Related articles - BL Direct - All 6 versions
D Zelent, H Najafi, S Odili, C Buettger, H … - Biochemical Society …, 2005 - bst.portlandpress.com The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate,
serves as the glucose sensor of insulin-producing b-cells. GK has thermodynamic, kinetic, regulatory
and molecular genetic characteristics that are ideal for its glucose sensor function and ... Cited by 42 - Related articles - Cached - All 9 versions
AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological …, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK
mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied
the GCK V62M mutation identified in two families and co-segregating with hyperglycemia ... Cited by 31 - Related articles - All 7 versions
- ►cell.com K Kamata, M Mitsuya, T Nishimura, J Eiki, Y Nagata - Structure, 2004 - Elsevier Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation
curve for its substrate, two properties that are important for its playing the role of a glucose sensor
in pancreas and liver. The molecular basis for these two properties is not well understood. ... Cited by 127 - Related articles - All 10 versions
[CITATION] Glucokinase
GI Bell, A Cuesta-Munoz, FM Matschinsky - … of Molecular Medicine. New York, Wiley, 2002 Cited by 28 - Related articles
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs, A … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report
here the effects of a novel glucokinase activator, LY2121260. The activator enhanced GK activity
via binding to the allosteric site located in the hinge region of the enzyme. LY2121260 ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►sciencesignaling.org [PDF] J Grimsby, R Sarabu, WL Corbett, NE Haynes, FT … - Science, 2003 - sciencemag.org Page 1. DOI: 10.1126/science.1084073 , 370 (2003); 301 Science et al. Joseph
Grimsby, in Diabetes Therapy Allosteric Activators of Glucokinase: Potential Role
www.sciencemag.org (this information is current as of January ... Cited by 187 - Related articles - All 12 versions
- ►diabetesjournals.org [PDF] B Mahalingam, A Cuesta-Munoz, EA Davis, FM … - Diabetes, 1999 - Am Diabetes Assoc Mutations in human glucokinase are implicated in the development of diabetes and
hypoglycemia. Human glucokinase shares 54% identical amino acid residues with human brain
hexokinase I. This similarity was used to model the structure of glucokinase by analogy to ... Cited by 52 - Related articles - BL Direct - All 4 versions
