HE Thomas, W Irawaty, R Darwiche, TC … - Diabetes, 2004 - Am Diabetes Assoc Proinflammatory cytokines are believed to be important in pancreatic β-cell
destruction in the development of type 1 diabetes. They act by upregulation of
genes including Fas and inducible nitric oxide synthase (iNOS), which have ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org WH Schott, BD Haskell, HM Tse, MJ Milton, JD … - Diabetes, 2004 - Am Diabetes Assoc Interleukin (IL)-1β and IL-18 are two cytokines associated with the
immunopathogenesis of diabetes in NOD mice. Both of these cytokines are cleaved
by caspase-1 to their biologically active forms. IL-1 is a proinflammatory ... Cited by 20 - Related articles - BL Direct - All 4 versions
EE Hamilton-Williams, SE Palmer, B Charlton, … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Type 1 diabetes occurs as a result of an autoimmune attack on the
insulin-producing beta cells. Although CD8 T cells have been implicated both
early and late in this process, the requirement for direct interaction ... Cited by 35 - Related articles - BL Direct - All 8 versions
- ►jimmunol.org R Darwiche, MMW Chong, P Santamaria, HE … - The Journal of Immunology, 2003 - Am Assoc Immnol Fas (CD95) is a potential mechanism of pancreatic cell death in type 1 diabetes.
cells do not constitutively express Fas but it is induced by cytokines. The
hypothesis of this study is that Fas expression should be measurable on ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►rupress.org SV Pakala, M Chivetta, CB Kelly, JD Katz - Journal of Experimental Medicine, 1999 - jem.rupress.org The islet-infiltrating and disease-causing leukocytes that are a hallmark of
insulin-dependent diabetes mellitus produce and respond to a set of cytokine
molecules. Of these, interleukin 1 , tumor necrosis factor (TNF)- , and ... Cited by 121 - Related articles - BL Direct - All 5 versions
I Chang, S Kim, JY Kim, N Cho, YH Kim, HS … - Diabetes, 2003 - Am Diabetes Assoc Recent studies incriminating tumor necrosis factor (TNF)- as the final effector
in pancreatic ß-cell death in type 1 diabetes underscore the potential role of
TNF- -dependent NF- B activation as an important modulator of pancreatic ... Cited by 46 - Related articles - BL Direct - All 5 versions
- ►rupress.org I Apostolou, Z Hao, K Rajewsky, H von … - Journal of Experimental Medicine, 2003 - jem.rupress.org In type 1 diabetes, autoimmune T cells cause destruction of pancreatic ß cells
by largely unknown mechanism. Previous analyses have shown that ß cell
destruction is delayed but can occur in perforin-deficient nonobese ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL Dudek, … - The Journal of Immunology, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell
destruction by direct cytotoxicity, inducing Fas expression, and up-regulating
class I MHC and chemokine expression to increase immune recognition. To ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org J Allison, HE Thomas, T Catterall, TWH Kay, A … - The Journal of Immunology, 2005 - Am Assoc Immnol In type 1 diabetes, many effector mechanisms damage the cell, a key one being
perforin/granzyme B production by CD8 + T cells. The death receptor pathway has
also been implicated in cell death, and we have therefore generated NOD ... Cited by 26 - Related articles - All 7 versions
- ►nih.gov [PDF] JO Sandberg, DL Eizirik, S Sandler - Clinical and Experimental Immunology, 1997 - pubmedcentral.nih.gov SUMMARY The effect of an IL-1 receptor antagonist on recurrence of
hyperglycaemia after syngeneic pancreatic islet transplantation to spontaneously
diabetic female NOD mice was investigated. The transplanted animals were ... Cited by 37 - Related articles - BL Direct - All 5 versions
