X Wang, H Li, D De Leo, W Guo, V Koshkin, IG Fantus, … - Diabetes, 2004 - Am Diabetes Assoc Gene and Protein Kinase Expression Profiling of ... Reactive Oxygen Species–Associated Lipotoxicity
in the ... Xiaolin Wang, 1 * Hui Li, 1,2 * Domenica De Leo, 1 Wanbei Guo, 2 Vasilij Koshkin, 1
I. George Fantus, 1,3 ... Adria Giacca, 1 Catherine B. Chan, 4 Sandy Der, 2 and Michael ... Cited by 50 - Related articles - BL Direct - All 4 versions
V Koshkin, X Wang, PE Scherer, CB Chan, MB … - Journal of Biological …, 2003 - ASBMB Excessive free fatty acid (FFA) exposure represents a potentially important diabetogenic condition
that can impair insulin secretion from pancreatic -cells. Because mitochondrial oxidative phosphorylation
is a main link between glucose metabolism and insulin secretion, in the present work we ... Cited by 64 - Related articles - BL Direct - All 5 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena, B Soria, … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids were tested in
ß(INS-1)-cells cultured in the absence of serum, a condition known to alter cell survival in various
systems. This may in part mimic the situation in type 1 or 2 diabetes where ß-cells are ... Cited by 82 - Related articles - BL Direct - All 8 versions
- ►endojournals.org C Carlsson, LA Hakan Borg, N Welsh - Endocrinology, 1999 - Endocrine Soc The aim of the present investigation was to study whether prolonged exposure of isolated rat
islets to the long chain fatty acid sodium palmitate leads to uncoupling of respiration. It was found
that culture of islets in the presence of palmitate abolished glucose-sensitive insulin ... Cited by 109 - Related articles - BL Direct - All 5 versions
PC Moore, MA Ugas, DK Hagman, SD Parazzoli, V … - Diabetes, 2004 - Am Diabetes Assoc Prolonged exposure to elevated levels of fatty acids adversely affects pancreatic β-cell
function. Here we investigated 1) whether ceramide synthesis, which we reported to mediate
fatty acid inhibition of insulin gene expression, also inhibits insulin secretion and 2) ... Cited by 43 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org AK Busch, D Cordery, GS Denyer, TJ Biden - Diabetes, 2002 - Am Diabetes Assoc Chronic lipid exposure is implicated in β-cell dysfunction in type 2 diabetes. We therefore used
oligonucleotide arrays to define global alterations in gene expression in MIN6 cells after 48-h
pretreatment with oleate or palmitate. Altogether, 126 genes were altered ≥1.9-fold by ... Cited by 86 - Related articles - BL Direct - All 7 versions
JW Joseph, V Koshkin, CY Zhang, J Wang, BB Lowell, … - Diabetes, 2002 - Am Diabetes Assoc Uncoupling protein 2 (UCP2) may act as an important regulator of insulin secretion. In this
study, β-cell function in UCP2-deficient mice was examined after a 45% high-fat diet (HFD) to
assess its role during the development of diet-induced type 2 diabetes. HFD-fed UCP2 ... Cited by 120 - Related articles - BL Direct - All 5 versions
- ►endojournals.org LX Li, F Skorpen, K Egeberg, IH Jorgensen, V Grill - Endocrinology, 2002 - Endocrine Soc A plausible theory on the functional importance of UCP-2 holds that regulation of this protein
provides a way to dissipate energy in situations of oversupply to a specific tissue or cell (1,
2). Restraining the build-up of excessive amounts of energy, stored (for example) as ... Cited by 40 - Related articles - BL Direct - All 4 versions
G Patanè, M Anello, S Piro, R Vigneri, F Purrello, AM … - Diabetes, 2002 - Am Diabetes Assoc In rat pancreatic islets chronically exposed to high glucose or high free fatty acid (FFA)
levels, glucose-induced insulin release and mitochondrial glucose oxidation are impaired. These
abnormalities are associated with high basal ATP levels but a decreased ... Cited by 102 - Related articles - BL Direct - All 6 versions
JW Joseph, V Koshkin, MC Saleh, WI Sivitz, CY … - Journal of Biological …, 2004 - ASBMB Free fatty acid induced β-cell defects are dependent on ... Jamie W. Joseph 1 , Vasilij Koshkin
1 , Monique C. Saleh 3 , William I. Sivitz 2 , ... Chen-Yu Zhang 4 , Bradford B. Lowell 4 , Catherine
B. Chan 3 , ... 1 Departments of Medicine and Physiology University of Toronto, Ontario, ... Cited by 90 - Related articles - BL Direct - All 5 versions
