L Marzban, G Trigo-Gonzalez, X Zhu, CJ … - Diabetes, 2004 - Am Diabetes Assoc Islet amyloid polypeptide (IAPP) (amylin), the major component of islet amyloid,
is produced by cleavage at the COOH- and NH 2 -termini of its precursor,
proIAPP, likely by the β-cell prohormone convertases (PC) 1/3 and PC2. ... Cited by 29 - Related articles - BL Direct - All 5 versions
CE Higham, RL Hull, L Lawrie, KIJ Shennan, JF … - European Journal of Biochemistry, 2000 - interscience.wiley.com Islet amyloid polypeptide (IAPP), amylin, is the constituent peptide of
pancreatic islet amyloid deposits which form in islets of Type 2 diabetic
subjects. Human IAPP is synthesized as a 67-residue propeptide in islet ... Cited by 29 - Related articles - BL Direct - All 4 versions
J Wang, J Xu, J Finnerty, M Furuta, DF … - Diabetes, 2001 - Am Diabetes Assoc Impaired processing of pro-islet amyloid polypeptide (proIAPP), the precursor of
the β-cell peptide islet amyloid polypeptide (IAPP) (amylin), has been
implicated in islet amyloid formation in type 2 diabetes. The prohormone ... Cited by 43 - Related articles - BL Direct - All 4 versions
MK Badman, KIJ Shennan, JL Jermany, K … - FEBS letters, 1996 - Elsevier Islet amyloid polypeptide (IAPP), 'amylin', is the component peptide of islet
amyloid formed in Type 2 diabetes. IAPP is expressed in islet β-cells and is
derived from a larger precursor, proIAPP, by proteolysis. An in vitro ... Cited by 49 - Related articles - All 6 versions
X Hou, Z Ling, E Quartier, A Foriers, F Schuit … - Diabetologia, 1999 - Springer Islet amyloid polypeptide (IAPP) is a 37 amino acid peptide that is produced by
pancreatic beta cells fol- lowing synthesis of (pre)pro-IAPP and proteolytic
cleavage at dibasic lys-arg residues [1]. The peptide is the predominant ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►shouxi.net JF Paulsson, GT Westermark - Diabetes, 2005 - Am Diabetes Assoc The amyloid present in the islets of Langerhans in type 2 diabetes is
polymerized islet amyloid polypeptide (IAPP). The precursor protein proIAPP is
posttranslationally modified, a process involving the removal of NH 2 - and ... Cited by 25 - Related articles - All 5 versions
- ►jbc.org [PDF] T Sanke, GI Bell, C Sample, AH Rubenstein, … - Journal of Biological Chemistry, 1988 - ASBMB Amyloid deposits occurring in the islets of Langer- hans in patients with
noninsulin-dependent diabetes mellitus and some insulinomas contain a 37-amino
acid peptide that is structurally related to calcitonin gene- related ... Cited by 80 - Related articles - All 4 versions
M Krampert, J Bernhagen, J Schmucker, A … - Chemistry & Biology, 2000 - Elsevier Results: We present a method for efficient recombinant expression and
purification of ProIAPP and a processing site mutant, mutProIAPP, as thioredoxin
(Trx) fusion proteins. Conformation and amyloidogenicity of cleaved ProIAPP ... Cited by 21 - Related articles - BL Direct - All 16 versions
P Westermark, U Engström, GT Westermark, … - Diabetes research and clinical practice, 1989 - ncbi.nlm.nih.gov Islet amyloid polypeptide (IAPP) is a 37-amino-acid putative hormone which is
expressed by islet B-cells and most probably is co-released with insulin. IAPP
is synthesized as an 89-amino-acid prepropeptide in which IAPP is flanked ... Cited by 37 - Related articles
K Park, CB Verchere - Journal of Biological Chemistry, 2001 - ASBMB Islet amyloid deposits are a characteristic pathologic lesion of the pancreas in
type 2 diabetes and are composed primarily of the islet beta cell peptide islet
amyloid polypeptide (IAPP or amylin) as well as the basement membrane ... Cited by 38 - Related articles - BL Direct - All 4 versions
