- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint
is the retinoblastoma protein (pRb), and this is regulated in part by the
activities of cyclin-dependent kinase (cdk)-4 and the D cyclins. ... Cited by 57 - Related articles - BL Direct - All 4 versions
X Zhang, JP Gaspard, Y Mizukami, J Li, F … - Diabetes, 2005 - Am Diabetes Assoc Cyclin D1 can stimulate proliferation by driving cells from the G1 into the
S-phase of the mammalian cell cycle. Previous animal studies have implicated the
G1-S transition as a key regulatory checkpoint governing the proliferation ... Cited by 32 - Related articles - All 5 versions
- ►nih.gov JA Kushner, MA Ciemerych, E Sicinska, LM … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol Regulation of adult ß-cell mass in pancreatic islets is essential to preserve
sufficient insulin secretion in order to appropriately regulate glucose
homeostasis. In many tissues mitogens influence development by stimulating ... Cited by 115 - Related articles - All 7 versions
I Cozar-Castellano, KK Takane, R Bottino, … - Diabetes, 2004 - Am Diabetes Assoc A lthough it is currently very clear that -cells can replicate, albeit slowly,
in vitro and in vivo, both basally and in response to a variety of maneuvers and
stimuli (rev. in 1–3), the key components of the cell cycle machinery in ... Cited by 2 - Related articles - All 2 versions
- ►diabetesjournals.org S Fatrai, L Elghazi, N Balcazar, C Cras- … - Diabetes, 2006 - Am Diabetes Assoc Proliferation is the major component for maintenance of β-cell mass in adult
animals. Activation of phosphoinositide 3-kinase/Akt-kinase pathway is a
critical regulator of β-cell mass. Pancreatic β-cell overexpression of ... Cited by 42 - Related articles - BL Direct - All 5 versions
RC Vasavada, JA Gonzalez-Pertusa, Y … - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Recent studies have demonstrated that human islet allograft transplantation can
be a successful therapeutic option in the treatment of patients with Type I
diabetes. However, this impressive recent advance is accompanied by a very ... Cited by 38 - Related articles - All 4 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
J Martín, SL Hunt, P Dubus, R Sotillo, F … - Oncogene, 2003 - nature.com Lack of Cdk4 expression in mice leads to insulin-deficient diabetes and female
infertility owing to a reduced number of pancreatic cells and
prolactin-producing pituitary lactotrophs, respectively. Cdk4 null mice ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org I Cozar-Castellano, M Haught, AF Stewart - Diabetes, 2006 - Am Diabetes Assoc The rate of pancreatic β-cell replication is extremely slow. For example,
Finegood et al. (1) report that 3% of rodent β-cells replicate every 24 h.
Kushner and colleagues (2) have recently reported that in older mice, this ... Cited by 11 - Related articles - BL Direct - All 5 versions
T Uchida, T Nakamura, N Hashimoto, T … - Nature medicine, 2005 - whitelabs.org The protein p27Kip1 regulates cell cycle progression in mammals by inhibiting
the activity of cyclin-dependent kinases (CDKs). Here we show that p27Kip1
progressively accumulates in the nucleus of pancreatic beta cells in mice ... Cited by 84 - Related articles - All 8 versions
