- ►diabetesjournals.org S Le Fur, C Le Stunff, C Dos Santos, P … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP) 2 is a member of the mitochondrial transporter
superfamily that uncouples proton entry in the mitochondrial matrix from ATP
synthesis. Although its physiological role remains to be established, UCP2 ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►physiology.org H Wang, WS Chu, T Lu, SJ Hasstedt, PA Kern, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance,
and impaired -cell function. Uncoupling protein-2 (UCP2) is a widely expressed
inner mitochondrial membrane protein. Common polymorphisms of the UCP2 gene ... Cited by 63 - Related articles - BL Direct - All 5 versions
LT Dalgaard, G Andersen, LH Larsen, TIA … - Obesity, 2003 - nature.com Research Methods and Procedures: The human UCP2 promoter was characterized by
reporter gene analysis in cell lines derived from skeletal muscle, white adipose
tissue, and embryonic tissue. We analyzed the core promoter for ... Cited by 23 - Related articles - BL Direct - All 3 versions
G Sesti, M Cardellini, MA Marini, S Frontoni, … - Diabetes, 2003 - Am Diabetes Assoc It was reported that the common −866G/A polymorphism in the promoter of the
human uncoupling protein-2 (UCP2) gene, which enhances its trascriptional
activity, is associated with increased mRNA levels in human adipocytes and ... Cited by 87 - Related articles - BL Direct - All 4 versions
F Krempler, H Esterbauer, R Weitgasser, C … - Diabetes, 2002 - Am Diabetes Assoc Obesity is frequently associated with type 2 diabetes. We previously observed an
association of a functional G/A polymorphism in the uncoupling protein 2 (UCP2)
promoter with obesity. The wild-type G allele was associated with reduced ... Cited by 95 - Related articles - BL Direct - All 4 versions
MD'Adamo, L Perego, M Cardellini, MA Marini, S … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane
carriers that uncouple pro-ton entry in the mitochondrial matrix from ATP
synthesis. The −866G/A polymorphism in the UCP2 gene, which enhances its ... Cited by 64 - Related articles - BL Direct - All 5 versions
A Marti, MS Corbalán, L Forga L, MA Martinez … - Nutrition, 2004 - Elsevier The association between risk of obesity and the UCP2 insertion allele was
estimated using multivariate logistic regression. Obesity risk among carriers of
the UCP2 insertion allele was slightly higher than among non-carriers ( ... Cited by 23 - Related articles - All 3 versions
TR Nagy, ML Blaylock, WT Garvey - Nutrition, 2004 - Elsevier In a “coupled” system, the oxidation of substrates generates a proton
gradient that is used to form adenosine triphosphate (ATP) from ADP via ATP
synthase (complex V). If the potential energy stored in the proton gradient ... Cited by 18 - Related articles - All 6 versions
O Ukkola, A Tremblay, G Sun, YC Chagnon, … - European journal of clinical nutrition, 2001 - ncbi.nlm.nih.gov OBJECTIVE: To evaluate the effects of uncoupling protein (UCP) 1, UCP2 and UCP3
gene variants on body composition and metabolic changes in response to chronic
overfeeding and the recovery after the period of overfeeding. SUBJECTS AND ... Cited by 41 - Related articles - BL Direct - All 3 versions
AF Reis, D Dubois-Laforgue, C Bellanné- … - Molecular Genetics and Metabolism, 2004 - Elsevier AG/A single nucleotide polymorphism (SNP) in the position −866 of the UCP2
promoter modulates UCP2 expression in adipose tissue and pancreatic β-cell, and
is associated with variations of body mass index (BMI) and insulin ... Cited by 16 - Related articles - All 3 versions
