- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E Wang, RA … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in insulin
resistance, but the precise nature of the lipid species that produce insulin resistance in human
muscle are unknown. Ceramides, either generated via activation of sphingomyelinase or ... Cited by 118 - Related articles - BL Direct - All 9 versions
M Straczkowski, I Kowalska, A Nikolajuk, S Dzienis- … - Diabetes, 2004 - Am Diabetes Assoc In vitro studies revealed that insulin resistance might be associated with the intracellular formation
of ceramide, the second messenger in the sphingomyelin signaling pathway. The aim of the
present study was to examine the content and composition of fatty acids in ceramide and ... Cited by 68 - Related articles - BL Direct - All 5 versions
MC Sullards, LJ Mandarino - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in insulin
resistance, but the precise nature of the lipid species that produce insulin resistance in human
muscle are unknown. Ceramides, either generated via activation of sphingomyelinase or ... Related articles - All 2 versions
- ►jbc.org [PDF] J Turinsky, DM O'sullivan, BP Bayly - Journal of Biological Chemistry, 1990 - ASBMB Diacylglycerol and Ceramides in Rat Tissues in Vivo 16881 observed in isolated muscles or
perfused hindquarters of obese rats (14-16). The second series of experiments was performed
on normal Sprague-Dawley rats and investigated whether 1,2-diacylglyc- erol ... Cited by 99 - Related articles - All 3 versions
- ►jbc.org JA Chavez, TA Knotts, LP Wang, G Li, RT … - Journal of Biological …, 2003 - ASBMB Multiple studies suggest that lipid oversupply to skeletal muscle contributes to the development
of insulin resistance, perhaps by promoting the accumulation of lipid metabolites capable of inhibiting
signal transduction. Herein we demonstrate that exposing muscle cells to particular ... Cited by 156 - Related articles - BL Direct - All 5 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and
the liver, and researchers have recently proposed two mechanisms by which excess adiposity
antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their ... Cited by 114 - Related articles - All 3 versions
DJ Powell, S Turban, A Gray, E Hajduch, HS … - Biochemical …, 2004 - pubmedcentral.nih.gov Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle
insulin resistance that may develop, in part, as a consequence of a direct inhibitory effect on
early insulin signalling events. Here we report work investigating the mechanism by ... Cited by 58 - Related articles - BL Direct - All 6 versions
C Schmitz-Peiffer, DL Craig, TJ Biden - Journal of Biological Chemistry, 1999 - ASBMB We have employed C2C12 myotubes to investigate lipid inhibition of insulin-stimulated signal
transduction and glucose metabolism. Cells were preincubated for 18 h in the absence or presence
of free fatty acids (FFAs) and stimulated with insulin, and the effects on glycogen ... Cited by 287 - Related articles - BL Direct - All 5 versions
- ►jbc.org S Stratford, KL Hoehn, F Liu, SA Summers - Journal of Biological Chemistry, 2004 - ASBMB The sphingolipid ceramide negatively regulates insulin action by inhibiting Akt/protein kinase
B (PKB), a serine/threonine kinase that is a central regulator of glucose uptake and anabolic
metabolism. Despite considerable attention, the molecular mechanism accounting for this ... Cited by 69 - Related articles - BL Direct - All 4 versions
E Hajduch, A Balendran, IH Batty, GJ Litherland, AS … - Diabetologia, 2001 - Springer The activation of phosphoinositide 3-kinase (PI3K) by insulin represents a key signalling event
in the hormonal stimulation of diverse cellular responses ... Ceramide impairs the insulin-dependent
membrane recruitment ... E.Hajduch 1 , A.Balendran 2 , IHBatty 1 , GJLitherland 1 , ... Cited by 90 - Related articles - BL Direct - All 3 versions
