- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of
glucagon-like peptide-1 (GLP-1) receptor-mediated signal transduction in the
pancreatic β-cell. Although GLP-1 is established to be a cAMP-elevating ... Cited by 127 - Related articles - BL Direct - All 6 versions
- ►nyu.edu [PDF] GL Peptide, RM Signal - DIABETES, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of
glucagon-like peptide-1 (GLP-1) receptor–mediated signal transduction in the
pancre- atic -cell. Although GLP-1 is established to be a cAMP- elevating ... Related articles - All 13 versions
- ►nih.gov [PDF] T Tsuboi, G da Silva Xavier, GG Holz, LS … - Biochemical Journal, 2003 - pubmedcentral.nih.gov Takashi TSUBOI*, Gabriela DA SILVA XAVIER*, George G. HOLZ†, Laurence S.
JOUAVILLE‡, Andrew P. THOMAS‡ and Guy A. RUTTER*1 *Henry Wellcome
Laboratories for Integrated Cell Signalling, Department of Biochemistry, ... Cited by 82 - Related articles - BL Direct - All 23 versions
Y Kashima, T Miki, T Shibasaki, N Ozaki, M … - Journal of Biological Chemistry, 2001 - ASBMB Incretins such as glucagon-like peptide-1 and gastric inhibitory
polypeptide/glucose-dependent insulinotropic peptide are known to potentiate
insulin secretion mainly through a cAMP/protein kinase A (PKA) signaling ... Cited by 191 - Related articles - BL Direct - All 3 versions
- ►jbc.org G Kang, JW Joseph, OG Chepurny, M Monaco, … - Journal of Biological Chemistry, 2003 - ASBMB The second messenger cAMP exerts powerful stimulatory effects on Ca 2+ signaling
and insulin secretion in pancreatic -cells. Previous studies of -cells focused
on protein kinase A (PKA) as a downstream effector of cAMP action. However, ... Cited by 146 - Related articles - BL Direct - All 23 versions
- ►rupress.org L Eliasson, X Ma, E Renstrom, S Barg, PO … - Journal of General Physiology, 2003 - jgp.rupress.org Measurements of membrane capacitance were applied to dissect the cellular
mechanisms underlying PKA-dependent and -independent stimulation of insulin
secretion by cyclic AMP. Whereas the PKA-independent ... Cited by 113 - Related articles - BL Direct - All 5 versions
- ►nyumed.org [PDF] G Holz - Hormone and Metabolic Research, 2004 - thieme-connect.com The GLP-1 receptor is a Class B heptahelical G-protein-coupled receptor that
stimulates cAMP production in pancreatic ?-cells. GLP-1 utilizes this receptor
to activate two distinct classes of cAMP-binding proteins: protein kinase A ... Cited by 38 - Related articles - All 32 versions
K Fujimoto, T Shibasaki, N Yokoi, Y Kashima, … - Journal of Biological Chemistry, 2002 - ASBMB We have previously shown that cAMP-binding protein cAMP-guanidine nucleotide
exchange factor II (GEFII) (or Epac2) interacting with Rim2 is involved in
cAMP-dependent, protein kinase A-independent exocytosis in pancreatic ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►shouxi.net G Kang, OG Chepurny, MJ Rindler, L Collis, … - The Journal of Physiology, 2005 - Physiological Soc The blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1) stimulates
cAMP production, promotes Ca 2+ influx, and mobilizes an intracellular source of
Ca 2+ in pancreatic β cells. Here we provide evidence that these actions ... Cited by 51 - Related articles - All 18 versions
- ►jbc.org T Shibasaki, Y Sunaga, K Fujimoto, Y … - Journal of Biological Chemistry, 2004 - ASBMB ATP, cAMP, and Ca 2+ are the major signals in the regulation of insulin granule
exocytosis in pancreatic cells. The sensors and regulators of these signals have
been characterized individually. The ATP-sensitive K + channel, acting as ... Cited by 49 - Related articles - BL Direct - All 4 versions
