- ►leptipro.org [PDF] JA Kushner, FG Haj, LD Klaman, MA Dow, BB … - Diabetes, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase-1b (Ptp1b) inhibits insulin and leptin signaling by
dephosphorylating specific tyrosine residues in their activated receptor
complexes. Insulin signals are mediated by tyrosine phosphorylation of the ... Cited by 29 - Related articles - BL Direct - All 16 versions
FG Haj, JM Zabolotny, YB Kim, BB Kahn, BG … - Journal of Biological Chemistry, 2005 - ASBMB Protein-tyrosine phosphatase 1B (PTP1B) is an important negative regulator of
insulin and leptin signaling in vivo. Mice lacking PTP1B (PTP1B–/– mice) are
hyper-responsive to insulin and leptin and resistant to diet-induced ... Cited by 37 - Related articles - All 9 versions
T Issad, N Boute, S Boubekeur, D Lacasa - Biochimie, 2005 - Elsevier PTP1B is a protein tyrosine-phosphatase predominantly located on the cystosolic
surface of the endoplasmic reticulum. This tyrosine-phosphatase plays a major
role in the regulation of the activity of the insulin receptor (IR). We ... Cited by 18 - Related articles - All 3 versions
- ►diabetesjournals.org W Qiu, RK Avramoglu, N Dubé, TM Chong, M … - Diabetes, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase-1B (PTP-1B) plays an important role in regulation
of insulin signal transduction, and modulation of PTP-1B expression seems to
have a profound effect on insulin sensitivity and diet-induced weight gain. ... Cited by 28 - Related articles - BL Direct - All 4 versions
J Montalibet, BP Kennedy - Biochemical pharmacology, 2004 - Elsevier Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as a
novel therapy to treat type 2 diabetes and obesity. In order to identify novel
PTP1B inhibitors, we have developed a robust screen in Saccharomyces ... Cited by 9 - Related articles - All 3 versions
JE Clampit, JL Meuth, HT Smith, RM Reilly, … - Biochemical and Biophysical Research …, 2003 - Elsevier Protein-tyrosine phosphatase-1B (PTP1B) has been implicated as a negative
regulator of insulin signaling. PTP1B dephosphorylates the insulin receptor and
insulin receptor substrates (IRS-1/2), inhibiting the insulin-signaling ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►nih.gov S Galic, C Hauser, BB Kahn, FG Haj, BG Neel, … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol The protein tyrosine phosphatase PTP1B is a negative regulator of insulin
signaling and a therapeutic target for type 2 diabetes. Our previous studies
have shown that the closely related tyrosine phosphatase TCPTP might also ... Cited by 47 - Related articles - All 11 versions
RJ Gum, LL Gaede, MA Heindel, JF Waring, JM … - Molecular Endocrinology, 2003 - Endocrine Soc TYPE 2 DIABETES is characterized by insulin resistance in tissues such as liver,
fat, and skeletal muscle (1). A variety of research efforts into type 2 diabetes
are directed at increasing insulin sensitivity by stimulating ... Cited by 26 - Related articles - BL Direct - All 4 versions
CM Rondinone, J Clampit, RJ Gum, BA Zinker, … - Biochemical and Biophysical Research …, 2004 - Elsevier Protein tyrosine phosphatase 1B (PTP1B) inhibition increases insulin sensitivity
and normalizes blood glucose levels in animals. The molecular events associated
with PTP1B inhibition that increase insulin sensitivity remain ... Cited by 5 - Related articles - All 4 versions
C Yang, K Cross, GJ Myatt, PE Blower, JF … - J. Med. Chem, 2004 - pubs.acs.org A new approach to predicting the biological activity of small molecule
pharmaceutics is demonstrated. Structural features of medicinal chemistry
building blocks are used as 2-D molecular descriptors. These descriptors ... Cited by 6 - Related articles - BL Direct - All 5 versions
