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Scholar Results 1 - 10 of about 101 related to Yang: Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose. (0.11 sec) 

Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose


XJ Yang, LM Kow, DW Pfaff, CV Mobbs - Diabetes, 2004 - Am Diabetes Assoc
Neurons in the ventromedial hypothalamus mediate some counterregulatory
responses to hypoglycemia and 2-deoxyglucose, but the mechanisms that mediate
these responses to glucose are unclear. In the present study, ventromedial ...
Cited by 44 - Related articles - BL Direct - All 6 versions

Hypothalamic neuronal activity responses to 3-hydroxybutyric acid, an endogenous organic …


T Minami, N Shimizu, S Duan, Y Oomura - Brain research, 1990 - Elsevier
To elucidate the anorectic action of the endogenous organic acid,
3-hydroxybutyric acid (3-HBA), its effects on neurons in both the rat
ventromedial hypothalamic nucleus (VMH) and the lateral hypothalamic area ...
Cited by 17 - Related articles - All 4 versions

Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose- …

- umdnj.edu [PDF] 
AA Dunn-Meynell, VH Routh, L Kang, L … - Diabetes, 2002 - Am Diabetes Assoc
Specialized neurons utilize glucose as a signaling molecule to alter their
firing rate. Glucose-excited (GE) neurons increase and glucose-inhibited (GI)
neurons reduce activity as ambient glucose levels rise. Glucose-induced ...
Cited by 116 - Related articles - BL Direct - All 8 versions

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell …

- diabetesjournals.org [PDF] 
XJ Yang, LM Kow, T Funabashi, CV Mobbs - Diabetes, 1999 - Am Diabetes Assoc
Glucose-responsive neurons in the ventromedial hypo- thalamus (VMH) are
stimulated when glucose increases from 5 to 20 mmol/l and are thought to play an
essential role in regulating metabolism. The present studies exam- ined the ...
Cited by 185 - Related articles - BL Direct - All 5 versions

Differential effects of glucose and lactate on glucosensing neurons in the ventromedial …

- diabetesjournals.org
Z Song, VH Routh - Diabetes, 2005 - Am Diabetes Assoc
Glucose directly alters the action potential frequency of glucosensing neurons
in the ventromedial hypothalamic nucleus (VMN). Glucose-excited neurons
increase, and glucose-inhibited neurons decrease, their action potential ...
Cited by 61 - Related articles - All 7 versions

Third ventricular alloxan reversibly impairs glucose counterregulatory responses

- diabetesjournals.org
NM Sanders, AA Dunn-Meynell, BE Levin - Diabetes, 2004 - Am Diabetes Assoc
Glucokinase (GK) is hypothesized to be the critical glucosensor of pancreatic
β-cells and hypothalamic glucosensing neurons. To understand the role of GK in
glucoprivic counterregulatory responses, we injected alloxan, a GK ...
Cited by 36 - Related articles - BL Direct - All 4 versions

Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus …

- rutgers.edu [PDF] 
L Kang, VH Routh, EV Kuzhikandathil, LD … - Diabetes, 2004 - Am Diabetes Assoc
To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging
and single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic
nucleus (VMN) neurons. Glucose-excited (GE) neurons increased and glucose- ...
Cited by 94 - Related articles - BL Direct - All 7 versions

Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat …

- nih.gov
EK Ainscow, S Mirshamsi, T Tang, MLJ … - The Journal of Physiology, 2002 - Physiological Soc
Glucose-responsive (GR) neurons from hypothalamic nuclei are implicated in the
regulation of feeding and satiety. To determine the role of intracellular ATP in
the closure of ATP-sensitive K + (K ATP ) channels in these cells and ...
Cited by 64 - Related articles - BL Direct - All 7 versions

Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic …


MA Borg, WV Tamborlane, GI Shulman, RS … - Diabetes, 2003 - Am Diabetes Assoc
We have previously reported that a glucosensor integrating hormonal responses to
hypoglycemia is located in the ventromedial hypothalamus (VMH) and that local
VMH glucose perfusion blocks counterregulatory hormone responses. To ...
Cited by 49 - Related articles - BL Direct - All 4 versions

Metabolic sensors: viewing glucosensing neurons from a broader perspective.


BE Levin - Physiology & behavior, 2002 - ncbi.nlm.nih.gov
Glucose is a critical substrate for brain and organ function. Specialized
glucosensing neurons, which are involved in the control of energy homeostasis
and neuroendocrine function, are located in specific anatomic locations in ...
Cited by 52 - Related articles - BL Direct - All 3 versions


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