S Blüher, M Ziotopoulou, JW Bullen, SJ … - Diabetes, 2004 - Am Diabetes Assoc To elucidate mechanisms of melanocortin action, we investigated the effects of a
melanocortin receptor agonist (melanotetan II [MTII]) in lean C57BL/6J and obese
(DIO, ob/ob, UCP1-DTA) mice. MTII administration (100 μg qidip) for 24 h ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org DD Pierroz, M Ziotopoulou, L Ungsunan, S … - Diabetes, 2002 - Am Diabetes Assoc High-fat diet-induced obesity (DIO) in rodents is associated with
hyperleptinemia and resistance to leptin, but the response to agents acting
downstream of leptin receptors remains unknown. We assessed the response of ... Cited by 102 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] G Li, Y Zhang, JT Wilsey, PJ Scarpace - Journal of Endocrinology, 2004 - Soc Endocrinology The effects of the chronic activation of the central melano- cortin (MC) system
by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF)
diet-induced obese (DIO) Sprague–Dawley rats. Six-day central infusion of ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►endojournals.org P Cettour-Rose, F Rohner-Jeanrenaud - Endocrinology, 2002 - Endocrine Soc The effects of a 3-d peripheral administration of an -MSH agonist, MTII, on body
weight and the expression of uncoupling proteins (UCPs) and carnitine
palmitoyltransferase-1 were determined in lean and genetically obese fa/fa ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org G Li, CV Mobbs, PJ Scarpace - Diabetes, 2003 - Am Diabetes Assoc Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and
hyperinsulinemic. For testing whether chronic activation of the central
melanocortin pathway can bypass the defective leptin signaling and ... Cited by 39 - Related articles - BL Direct - All 5 versions
BS Hamilton, HN Doods - Obesity, 2002 - nature.com Research Methods and Procedures: Ex-breeder Chbb:Thom rats (350 to 400 g) were
divided into two groups: highly palatable food (HPF) and normal rat chow (RC).
Both groups had ab libitum access to rat chow. The HPF group had access to ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►endojournals.org DL Williams, RR Bowers, TJ Bartness, JM … - Endocrinology, 2003 - Endocrine Soc Central administration of melanocortin 3 and 4 receptor (MC3/4-R) agonists
increases energy expenditure, with the hypothalamus commonly held as the primary
site of action. It is also clear, however, that MC4-R are expressed in ... Cited by 46 - Related articles - BL Direct - All 5 versions
P Trivedi, M Jiang, CC Tamvakopoulos, X … - Brain research, 2003 - Elsevier Melanotan-II (MT-II), a cyclic heptapeptide, is a potent, non-selective
melanocortinergic agonist. When administered centrally or systemically, MT-II
elicited a profound inhibitory effect on food intake in rodents, presumably ... Cited by 28 - Related articles - All 5 versions
- ►endojournals.org DJ Clegg, SC Benoit, EL Air, A Jackman, P … - Endocrinology, 2003 - Endocrine Soc The hypothalamic melanocortin (MC) system provides a critical inhibitory control
on food intake and body weight. Because access to high-fat (HF) diets is
associated with the development of obesity, we hypothesized that increased ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org N Hoggard, DV Rayner, SL Johnston, JR … - Journal of molecular endocrinology, 2004 - Soc Endocrinology The melanocortin system coordinates the maintenance of energy balance via the
regulation of both food intake and energy expenditure. Leptin, a key adipogenic
hormone involved in the regulation of energy balance is thought to act by ... Cited by 17 - Related articles - All 4 versions
