- ►diabetesjournals.org ML Evans, RJ McCrimmon, DE Flanagan, T … - Diabetes, 2004 - Am Diabetes Assoc It has been postulated that specialized glucose-sensing neurons in the
ventromedial hypothalamus (VMH) are able to detect falling blood glucose and
trigger the release of counterregulatory hormones during hypoglycemia. The ... Cited by 74 - Related articles - BL Direct - All 5 versions
RJ McCrimmon, X Fan, Y Ding, W Zhu, RJ … - Diabetes, 2004 - Am Diabetes Assoc The mechanisms by which specialized glucose-sensing neurons within the
hypothalamus are able to detect a falling blood glucose remain largely unknown
but may be linked to some gauge of neuronal energy status. We sought to ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org RJ McCrimmon, ML Evans, X Fan, EC McNay, … - Diabetes, 2005 - Am Diabetes Assoc The mechanism(s) by which glucosensing neurons detect fluctuations in glucose
remains largely unknown. In the pancreatic β-cell, ATP-sensitive K + channels
(K ATP channels) play a key role in glucosensing by providing a link ... Cited by 24 - Related articles - BL Direct - All 6 versions
DMR Rev - Diabetes Metab Res Rev, 2003 - umdnj.edu Diabetes Metab Res Rev 2003; 19: 348–356. Published online 12 August 2003 in
Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/dmrr.404 ...
Departments of Pharmacology & Physiology and Neurosciences, New Jersey ... Cited by 34 - Related articles - View as HTML - BL Direct - All 5 versions
- ►diabetesjournals.org RJ McCrimmon, X Fan, H Cheng, E McNay, O … - Diabetes, 2006 - Am Diabetes Assoc Defective counterregulatory responses (CRRs) to hypoglycemia are associated with
a marked increase in the risk of severe hypoglycemia. The mechanisms leading to
the development of defective CRRs remain largely unknown, although they are ... Cited by 28 - Related articles - BL Direct - All 5 versions
L Kang, VH Routh, EV Kuzhikandathil, LD … - Diabetes, 2004 - Am Diabetes Assoc To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging
and single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic
nucleus (VMN) neurons. Glucose-excited (GE) neurons increased and glucose- ... Cited by 94 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] WP Borg, MJ During, RS Sherwin, MA Borg, … - Journal of Clinical Investigation, 1994 - pubmedcentral.nih.gov Abstract The central nervous system has been implicated in the activa- tion of
counterregulatory hormone release during hypoglyce- mia. However, the precise
loci involved are not established. To determine the role of the ... Cited by 127 - Related articles - BL Direct - All 6 versions
MA Borg, WV Tamborlane, GI Shulman, RS … - Diabetes, 2003 - Am Diabetes Assoc We have previously reported that a glucosensor integrating hormonal responses to
hypoglycemia is located in the ventromedial hypothalamus (VMH) and that local
VMH glucose perfusion blocks counterregulatory hormone responses. To ... Cited by 49 - Related articles - BL Direct - All 4 versions
T Miki, B Liss, K Minami, T Shiuchi, A Saraya … - Nat Neurosci, 2001 - mrcanu.pharm.ox.ac.uk KATP channels are found in many tissues, including skeletal and smooth muscle,
heart, pancreatic β-cells, pituitary, and brain1. These channels are thought to
regulate various cellular func- tions such as hormone secretion2, ... Cited by 227 - Related articles - View as HTML - BL Direct - All 6 versions
