- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, S Bertera, M … - Diabetes, 2002 - Am Diabetes Assoc The most commonly used technical approach to isolate human pancreatic islets
intended for allotransplants generates a product that is hampered by mechanical
and chemical insults, which dramatically reduce the mass of viable and ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►unil.ch [PDF] S Abdelli, J Ansite, R Roduit, T Borsello, I … - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from a progressive decrease
in β-cell mass and function (1). The mediators of β-cell dysfunction and
destruction include macrophages, T-cells and their inflammatory products, ... Cited by 50 - Related articles - BL Direct - All 8 versions
T Matsuda, K Omori, T Vuong, M Pascual, L … - American Journal of Transplantation, 2005 - interscience.wiley.com Nonspecific inflammation is associated with primary graft nonfunction (PNF).
Inflammatory islet damage is mediated at least partially by pro-inflammatory
cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α ... Cited by 39 - Related articles - All 4 versions
U Johansson, A Olsson, S Gabrielsson, B … - Biochemical and Biophysical Research …, 2003 - Elsevier Expression of immune modulating mediators in human Islets of Langerhans could
have important implications for development of autoimmunity in type 1 diabetes
and influence the outcome of clinical islet transplantation. Islets ... Cited by 67 - Related articles - All 5 versions
AN Balamurugan, Y Chang, JJ Fung, M Trucco … - American Journal of Transplantation, 2003 - interscience.wiley.com Worldwide growing interest in reproducing the result of the Edmonton protocol in
islet transplantation trials poses the problem of paucity of donors to supply
sufficient amount of islets for clinical use. Improved outcomes include ... Cited by 12 - Related articles - BL Direct - All 3 versions
S Bertera, ML Crawford, AM Alexander, GD … - Diabetes, 2003 - Am Diabetes Assoc Islet transplantation is a promising cure for diabetes. However, inflammation,
allorejection, and recurrent autoimmune damage all may contribute to early graft
loss. Pancreatic islets express lower levels of antioxidant genes than most ... Cited by 68 - Related articles - BL Direct - All 4 versions
JG Avila, T Tsujimura, J Oberholzer, T … - Cell transplantation, 2003 - ingentaconnect.com Printed in the USA. All rights reserved. ... Copyright 2003 Cognizant Comm.
Corp. www.cognizantcommunication.com ... Improvement of Pancreatic Islet
Isolation Outcomes Using Glutamine ... JG Avila,*† T. Tsujimura,*† J. ... Cited by 22 - Related articles - BL Direct - All 3 versions
J Avila, B Barbaro, A Gangemi, T Romagnoli, … - American Journal of Transplantation, 2005 - ccmjournal.org Oxidative stress during islet isolation induces a cascade of events injuring
islets and hampering islet engraftment. This study evaluated islet isolation and
transplantation outcomes after intra-ductal glutamine administration. Human ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►shouxi.net H Johansson, A Lukinius, L Moberg, T Lundgren … - Diabetes, 2005 - Am Diabetes Assoc There are strong indications that only a small fraction of grafts successfully
engraft in clinical islet transplantation. One explanation may be the instant
blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, ... Cited by 79 - Related articles - All 6 versions
