- ►diabetesjournals.org AP Olcott, G Tocco, J Tian, D Zekzer, J Fukuto, L … - Diabetes, 2004 - Am Diabetes Assoc Reactive oxygen species, such as superoxide, and nitrogen oxides, such as peroxynitrite, are
thought to contribute to ß-cell destruction during the disease process that leads to type 1
diabetes. EUK-8 is a member of a new class of synthetic salen-manganese compounds ... Cited by 17 - Related articles - BL Direct - All 4 versions
G Tocco, B Illigens, Y Iwamoto, Y Akiyama, GA … - Human Immunology, 2003 - Elsevier The role of highly reactive oxygen species (ROS) in the rejection of transplanted tissues is
unknown. Here, we studied the effects of scavengers of ROS on the rejection of fully allogeneic
skin grafts in mice. To test this, we used a series of synthetic compounds (EUK-8, -134 ... Cited by 2 - Related articles
A Barbu, N Welsh - Diabetologia, 2004 - Springer To the Editor: We have reason to believe that cell viability bioassays that utilise tetrazolium salts
are unsuitable for as- sessment of islet cell viability following treatment with the cy- tokines
IL-1 and IFN-γ. Tetrazolium salts, such as MTT and XTT, are reduced by living cells to ... Cited by 3 - Related articles - All 3 versions
M Gembal, J Druzyńska, S Andrzejewska, W … - Endokrynol …, 1993 - grande.nal.usda.gov Title: Protective effect of allopurinol, alpha-tocopherol and chlorpromazine on rat pancreatic islets
stored prior to transplantation. Author: Gembal, M : Druzynska, J : Andrzejewska, S :
Arendarczyk, W : Wojcikowski, C Citation: Endokrynol-Pol. 1993; 44(2): 147-50 Abstract: ... Cited by 3 - Related articles - Cached - All 3 versions
ML Brown, M Braun, L Cicalese, C Rastellini - Transplantation proceedings, 2005 - Elsevier Islet transplantation success is limited by the posttransplant inflammatory response, and we are
investigating the ability of antioxidants to neutralize this islet damage. We have shown that pyruvate
can enhance the engraftment and functionality of a suboptimal islet mass in rats. The ... Cited by 5 - Related articles - All 6 versions
T Meyer, G Wierse, W Weinrebe, J Treuner, D … - Anticancer research, 1997 - cat.inist.fr Cyclophosphamide(CP) and Ifosfamide(IF) are of great importance in the therapy of
neuroblastoma(NB). They are prodrugs which have to be activated by microsomes in order to
become active compounds. We established a test system which allowed the activation of ... Cited by 4 - Related articles - BL Direct - All 2 versions
J Irie, A Shimada, Y Oikawa, T Shigihara, T Saruta - Diabetologia, 2004 - Springer Aims/hypothesis. Type 1 diabetes mellitus is caused by autoimmune pancreatic beta cell
destruction, and the destructive process involves several molecular mecha- nisms including
oxygen-reactive species. A cysteine derivative, N-acetyl-cysteine, is widely used as an ... Cited by 5 - Related articles - BL Direct - All 4 versions
C Moriscot, S Candel, V Sauret, J Kerr-Conte, MJ … - Diabetes and Metabolism, 2007 - Elsevier Following MnTMPyP treatment, ROS production in INS-1 cells was reduced by 4- to 20-fold upon
HX/XO challenge and up to 2-fold upon SIN-1 stress. This phenomenon correlated with higher
viability measured by WST-1 or Live/Dead ® test. MnTMPyP preserved islet viability upon ... Cited by 5 - Related articles - All 3 versions
- ►jbc.org JY Yang, J Walicki, A Abderrahmani, M Cornu, G … - Journal of Biological …, 2005 - ASBMB Apoptosis of pancreatic cells is implicated in the onset of type 1 and type 2 diabetes.
Consequently, strategies aimed at increasing the resistance of cells toward apoptosis could be
beneficial in the treatment of diabetes. RasGAP, a regulator of Ras and Rho GTPases, is ... Cited by 6 - Related articles - BL Direct - All 5 versions
