T Ogata, L Li, S Yamada, Y Yamamoto, Y Tanaka, I … - Diabetes, 2004 - Am Diabetes Assoc Conophylline is a vinca alkaloid extracted from the tropical plant Ervatamia microphylla and has
been shown to induce differentiation of pancreatic AR42J cells. In the present study, we investigated
the effect of conophylline on the differentiation of pancreatic precursor cells. In the rat ... Cited by 20 - Related articles - BL Direct - All 4 versions
K Umezawa, A Hiroki, M Kawakami, H Naka, I Takei … - Biomedicine & …, 2003 - Elsevier We set up a screening system to detect low-molecular-weight compounds that induce insulin
expression in pancreatic acinar carcinoma AR42J cells. They can differentiate into insulin-producing
cells with neuron-like morphological change when treated with activin A. We employed ... Cited by 13 - Related articles - All 3 versions
I Kojima, K Umezawa - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Reduction of the β cell mass is critical in the pathogenesis of diabetes mellitus. The discovery
of agents, which induce differentiation of pancreatic progenitors to β cells, would be useful to
develop a new therapeutic approach to treat diabetes. To identify a new agent to ... Cited by 10 - Related articles - All 4 versions
TS Kam, KY Loh, C Wei - Journal of Natural Products, 1993 - pubs.acs.org Journal of Natural Products Vol. 56, NO. 11,Pp. 1865-1871, November 1993 ... CONOPHYLLJNE
AND CONOPHYLLIDINE: NEW DIMERIC ALKALOIDS FROM TABERNAEMONTANA DNARICATA ... TOH-SEOK KAhf,* KAH-YENG LOH, and CHEN WEI Department of Chemistry, ... Cited by 20 - Related articles - BL Direct - All 4 versions
R Kitamura, T Ogata, Y Tanaka, K Motoyoshi, M … - Endocrine …, 2007 - ncbi.nlm.nih.gov Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and
betacellulin, respectively. We examined the effect of conophylline and betacellulin-delta4 on
beta cell differentiation. In AR42J cells, conophylline and betacellulin-delta4 converted ... Cited by 5 - Related articles - BL Direct
- ►physiology.org L Li, M Seno, H Yamada, I Kojima - American Journal of …, 2003 - Am Physiological Soc Betacellulin (BTC) induces differentiation of pancreatic -cells and promotes regeneration of
-cells in experimental diabetes. The present study was conducted to determine if BTC improved
glucose metabolism in severe diabetes induced by a high dose of streptozotocin (STZ) in ... Cited by 36 - Related articles - BL Direct - All 3 versions
K Umezawa, T Taniguchi, M Toi, T Ohse, N … - … under experimental and …, 1996 - ncbi.nlm.nih.gov Conophylline, a new vinca alkaloid isolated from the plant Ervatamia microphylla induced normal
flat morphology in K-ras-NRK and K-ras-NIH cell lines, and lowered the increased uptake of
2-deoxyglucose in K-ras-NRK cells. Conophylline inhibited the growth of K-ras-NRK cells, ... Cited by 9 - Related articles - BL Direct - All 3 versions
TS Kam, HS Pang, TM Lim - Organic & biomolecular chemistry, 2003 - rsc.org The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided
a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine,
N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophyllinine ... Cited by 9 - Related articles - BL Direct - All 7 versions
[CITATION] Gene expression profiling of new β cells: evidence for differentiating β cells …
