- ►montreal-diabetes-research-center.org [PDF] PC Moore, MA Ugas, DK Hagman, SD … - Diabetes, 2004 - Am Diabetes Assoc Prolonged exposure to elevated levels of fatty acids adversely affects
pancreatic β-cell function. Here we investigated 1) whether ceramide synthesis,
which we reported to mediate fatty acid inhibition of insulin gene ... Cited by 43 - Related articles - BL Direct - All 7 versions
- ►nih.gov DK Hagman, LB Hays, SD Parazzoli, V … - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to
both defective insulin secretion from the pancreatic beta cell and peripheral
insulin resistance in type 2 diabetes. Previously, we have shown that ... Cited by 42 - Related articles - BL Direct - All 10 versions
CL Kelpe, PC Moore, SD Parazzoli, B … - Journal of Biological Chemistry, 2003 - ASBMB Chronic exposure to elevated levels of fatty acids impairs pancreatic beta cell
function, a phenomenon thought to contribute to the progressive deterioration of
insulin secretion in type 2 diabetes. We have previously demonstrated that ... Cited by 66 - Related articles - BL Direct - All 6 versions
X Wang, H Li, D De Leo, W Guo, V Koshkin, … - Diabetes, 2004 - Am Diabetes Assoc Gene and Protein Kinase Expression Profiling of ... Reactive Oxygen
Species–Associated Lipotoxicity in the ... Xiaolin Wang, 1 * Hui Li, 1,2 *
Domenica De Leo, 1 Wanbei Guo, 2 Vasilij Koshkin, 1 I. George Fantus, 1,3 Cited by 50 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AI Oprescu, G Bikopoulos, A Naassan, EM … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Forty-eight–hour infusion of oleate decreased the insulin and
C-peptide responses to a hyperglycemic clamp (P < 0.01), an effect prevented by
coinfusion of the antioxidants N-acetylcysteine (NAC) and taurine. Similar ... Cited by 21 - Related articles - BL Direct - All 3 versions
N Leung, T Sakaue, A Carpentier, K Uffelman … - Diabetologia, 2004 - Springer Aims/hypothesis. A prolonged increase of plasma NEFA impairs acute
glucose-stimulated insulin secre- tion (GSIS) in vitro and in vivo. Our study
therefore examined the combined effect of increased plasma NEFA and glucose ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►jbc.org JS Harmon, R Stein, RP Robertson - Journal of Biological Chemistry, 2005 - ASBMB Glucose toxicity in pancreatic islet beta cells causes loss of insulin gene
expression, content, and secretion due to loss of binding of transcription
factors, most notably PDX-1 and RIPE-3b1 activator, to the promoter region ... Cited by 63 - Related articles - All 8 versions
- ►diabetesjournals.org DK Hagman, MG Latour, SK Chakrabarti, G … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Prolonged exposure of isolated islets of Langerhans to elevated
levels of fatty acids, in the presence of high glucose, impairs insulin gene
expression via a transcriptional mechanism involving nuclear exclusion of ... Cited by 5 - Related articles - BL Direct - All 4 versions
- ►physiology.org TT Goh, TM Mason, N Gupta, A So, TKT Lam, L … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc We determined the effect of 48-h elevation of plasma free fatty acids (FFA) on
insulin secretion during hyperglycemic clamps in control female Wistar rats
(group a) and in the following female rat models of progressive -cell ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids
were tested in ß(INS-1)-cells cultured in the absence of serum, a condition
known to alter cell survival in various systems. This may in part mimic the ... Cited by 82 - Related articles - BL Direct - All 8 versions
