X Qin, A Goldfine, N Krumrei, L Grubissich, J … - Diabetes, 2004 - Am Diabetes Assoc Micro- and macrovascular diseases are major causes of morbidity and mortality in
the diabetic population, but the cellular and molecular mechanisms that link
hyperglycemia to these complications remain incompletely understood. We ... Cited by 38 - Related articles - BL Direct - All 4 versions
X Qin, N Krumrei, L Grubissich, M Dobarro, H … - Immunity, 2003 - Elsevier Basal complement activity presents a potential danger for “self” cells that
are tightly protected by complement regulators including CD59. Mice express two
Cd59 genes (mCd59a and mCd59b); mCd59b has approximately a 6-fold higher ... Cited by 34 - Related articles - BL Direct - All 11 versions
- ►pnas.org J Acosta, J Hettinga, R Flückiger, N Krumrei, … - Proceedings of the National Academy of Sciences, 2000 - National Acad Sciences Activated terminal complement proteins C5b to C9 form the membrane attack
complex (MAC) pore. Insertion of the MAC into endothelial cell membranes causes
the release of growth factors that stimulate tissue growth and ... Cited by 80 - Related articles - BL Direct - All 9 versions
GB Rosoklija, AJ Dwork, DS Younger, G … - Acta neuropathologica, 2000 - Springer Abstract Quantitative immunocytochemical analysis of complement proteins (CP)
was performed on sural nerve biopsies from 15 patients with diabetic neuropathy
(DN) and 18 nondiabetic patients with other forms of chronic neuropathy ... Cited by 20 - Related articles - BL Direct - All 3 versions
X Qin, S Ferris, W Hu, F Guo, G Ziegeler, JA … - Genes and Immunity, 2006 - nature.com The complement regulatory protein CD59 inhibits formation of the membrane attack
complex (MAC), the terminal effector of the complement system. There are two
mouse Cd59 genes in mice but only one in humans. In the work reported here ... Cited by 7 - Related articles - BL Direct - All 3 versions
N Uesugi, N Sakata, M Nangaku, M Abe, S … - American Journal of Kidney Diseases, 2004 - Elsevier Although recent studies have emphasized the pathogenic role of intrarenal
muscular arteries in patients with diabetic nephropathy, notice has not been
taken of their pathological characteristics. We focused on medial smooth ... Cited by 13 - Related articles - BL Direct - All 12 versions
J Zhang, C Gerhardinger, M Lorenzi - Diabetes, 2002 - Am Diabetes Assoc Diabetic retinal microangiopathy is characterized by increased permeability,
leukostasis, microthrombosis, and apoptosis of capillary cells, all of which
could be caused or compounded by activation of complement. In this study, ... Cited by 48 - Related articles - BL Direct - All 4 versions
A Accardo-Palumbo, G Triolo, G Colonna- … - Diabetologia, 2000 - Springer Several lines of evidence suggest that one of the pri- mary events in the course
of diabetic vascular pathol- ogy is an alteration affecting the endothelial cell
func- tion, including abnormalities of vessel tone and per- meability, ... Cited by 15 - Related articles - BL Direct - All 4 versions
CS Davies, CL Harris, BP Morgan - Immunology, 2005 - pubmedcentral.nih.gov Type 1 diabetes is associated with anaemia. Although the underlying mechanisms
remain unclear, the accompanying reticulocytosis implies that erythrocyte
lifespan in the circulation is shortened. Among the factors that permit ... Cited by 15 - Related articles - All 7 versions
X Qin, T Miwa, H Aktas, M Gao, C Lee, YM … - Mammalian Genome, 2001 - Springer 1 Harvard Medical School, Laboratory for Membrane Transport, 240 Longwood Ave.,
C1-607, Boston, Massachusetts 02115, USA 2 Center for Experimental Therapeutics
and Dept. of Pharmacology, Univ. of Pennsylvania School of Medicine, ... Cited by 28 - Related articles - BL Direct - All 2 versions
