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Scholar Results 1 - 10 of about 101 related to Sasaki: Gene therapy using replication-defective herpes simplex virus vectors expressing.... (0.14 sec) 

Gene therapy using replication-defective herpes simplex virus vectors expressing …

- diabetesjournals.org
K Sasaki, MB Chancellor, WF Goins, MW Phelan, JC … - Diabetes, 2004 - Am Diabetes Assoc
Diabetic cystopathy is one of the common complications of diabetes and current therapy is
limited. In the present study, the effects of gene therapy, using replication-defective herpes simplex
virus type 1 (HSV-1) vectors to deliver and express the nerve growth factor (NGF) gene ...
Cited by 38 - Related articles - BL Direct - All 5 versions

Herpes simplex virus mediated nerve growth factor expression in bladder and …


WF GOINS, N YOSHIMURA, MW PHELAN, T … - The Journal of urology, 2001 - Elsevier
Diabetic cystopathy resulting from sensory neuropathy may potentially be treated by direct gene
therapy. It has been suggested that nerve growth factor (NGF) has an ameliorative effect in preventing
the death in diabetes of afferent dorsal root ganglion neurons, which control bladder ...
Cited by 59 - Related articles - BL Direct - All 6 versions

Protective effect of herpes simplex virus-mediated neurotrophin gene transfer in …

- oxfordjournals.org
M Chattopadhyay, J Goss, D Wolfe, WC Goins, S … - Brain, 2004 - Oxford Univ Press
Attempts to develop clinical treatments for neuropathy using neurotrophins have not been
successful. We tested whether neurotrophin gene delivery to dorsal root ganglia (DRGs) using
non-replicating herpes simplex virus (HSV)-based vectors could prevent the development ...
Cited by 30 - Related articles - BL Direct - All 5 versions

Diabetic cystopathy correlates with a long-term decrease in nerve growth factor …


K Sasaki, MB Chancellor, MW Phelan, T Yokoyama, … - The Journal of urology, 2002 - Elsevier
At 6 and 12 weeks after the induction of diabetes with streptozotocin (65 mg./kg.
intraperitoneally) the effects of diabetes on Aδ afferent fiber dependent, conscious voiding were
evaluated by metabolic cage measurements and awake cystometry. The effects of ...
Cited by 44 - Related articles - BL Direct - All 9 versions

HSV vector-mediated transduction and GDNF secretion from adipose cells


J Fradette, D Wolfe, WF Goins, S Huang, RM Flanigan, … - Gene Therapy, 2004 - nature.com
The accessibility of adipose tissue and its ability to secrete various bioactive molecules suggest
that adipose cells may be attractive targets for gene therapy applications. Here, we report the
use of highly defective herpes simplex virus (HSV) vectors as suitable gene transfer ...
Cited by 10 - Related articles - All 3 versions

Effect of genetic background and culture conditions on the production of …


A Ozuer, JB Wechuck, WF Goins, D Wolfe, … - Biotechnology and …, 2002 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to display style sheets.
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functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Cited by 22 - Related articles - BL Direct - All 5 versions

Herpes simplex-mediated gene transfer of nerve growth factor protects against …

- diabetesjournals.org
JR Goss, WF Goins, D Lacomis, M Mata, JC Glorioso, … - Diabetes, 2002 - Am Diabetes Assoc
Peripheral neuropathy is a common and debilitating complication of diabetes. In animal
models, neurotrophic factors can prevent progression of the neuropathy, but adverse effects
prevent systemic administration in adequate doses to treat human disease. We examined ...
Cited by 80 - Related articles - BL Direct - All 6 versions

α1-Adrenergic mechanism in diabetic urethral dysfunction in rats


K TORIMOTO, Y HIRAO, H MATSUYOSHI, WC de … - The Journal of urology, 2005 - Elsevier
In diabetic rats the intravesical pressure thresholds for inducing urethral relaxation and the lowest
urethral pressure (UPP nadir) during urethral relaxation were significantly higher by 142% and
86%, respectively, than in normal rats, while baseline UPPs were not significantly ...
Cited by 8 - Related articles - All 6 versions

Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord …


J Liu, D Wolfe, S Hao, S Huang, JC Glorioso, M Mata, … - Molecular Therapy, 2004 - Elsevier
Neuropathic pain after spinal cord injury (SCI) represents a difficult problem that is commonly
refractory to conventional medical management. To determine if spinal release of γ-amino butyric
acid (GABA) could reduce below-level central neuropathic pain after SCI, we constructed ...
Cited by 45 - Related articles - All 4 versions

Safety and biodistribution studies of an HSV multigene vector following intracranial …


D Wolfe, A Niranjan, A Trichel, C Wiley, A Ozuer, E … - Gene …, 2004 - pubmedcentral.nih.gov
Malignant glioma is a fatal human cancer in which surgery, chemo- and radiation therapies are
ineffective. Therapeutic gene transfer used in combination with current treatment methods may
augment their effectiveness with improved clinical outcome. We have shown that ...
Cited by 10 - Related articles - BL Direct - All 4 versions


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