JE Kim, J Chen - Diabetes, 2004 - Am Diabetes Assoc Adipocyte differentiation is a developmental process that is critical for
metabolic homeostasis and nutrient signaling. The mammalian target of rapamycin
(mTOR) mediates nutrient signaling to regulate cell growth, proliferation, ... Cited by 42 - Related articles - BL Direct - All 4 versions
HJ Cho, J Park, HW Lee, YS Lee, JB Kim - Biochemical and biophysical research communications, 2004 - Elsevier Here, we demonstrated that inhibition of mTOR with rapamycin has negative
effects on adipocyte differentiation and insulin signaling. Rapamycin
significantly reduced expression of most adipocyte marker genes including ... Cited by 30 - Related articles - All 6 versions
- ►nih.gov O Le Bacquer, E Petroulakis, S Paglialunga, … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The most common pathology associated with obesity is insulin resistance, which
results in the onset of type 2 diabetes mellitus. Several studies have
implicated the mammalian target of rapamycin (mTOR) signaling pathway in ... Cited by 44 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org M Krebs, B Brunmair, A Brehm, M Artwohl, J … - Diabetes, 2007 - Am Diabetes Assoc Type 2 diabetes is closely linked to obesity and insulin resistance (1–3). In
addition to polygenic predisposition, environmental factors including quality
and quantity of food supply, dietary behavior, and physical activity are of ... Cited by 26 - Related articles - BL Direct - All 5 versions
A Bell, L Grunder, A Sorisky - Obesity, 2000 - nature.com Objective: The immunosuppressant drug rapamycin, has been reported to inhibit
3T3-L1 adipocyte differentiation by interfering with critical postconfluent
mitoses that are required early on for successful differentiation of this ... Cited by 33 - Related articles - BL Direct - All 2 versions
A Gagnon, S Lau, A Sorisky - Journal of Cellular Physiology, 2001 - interscience.wiley.com Inhibition of insulin-induced 3T3-L1 preadipocyte differentiation by rapamycin
has been attributed to a blockade of the early critical clonal expansion phase
of the adipogenic program. Rapamycin binds to, and inhibits, mTOR ... Cited by 26 - Related articles - BL Direct - All 2 versions
- ►shouxi.net F Tremblay, M Krebs, L Dombrowski, A Brehm, … - Diabetes, 2005 - Am Diabetes Assoc To examine the molecular mechanisms by which plasma amino acid elevation impairs
insulin action, we studied seven healthy men twice in random order during
infusion of an amino acid mixture or saline (total plasma amino acid ∼6 ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►pnas.org [PDF] WC Yeh, BE Bierer, SL McKnight - Proceedings of the National Academy of Sciences, 1995 - National Acad Sciences Page 1. Proc. Natl. Acad. Sci. USA Vol. 92, pp. 11086-11090, November 1995
Biochemistry Rapamycin inhibits clonal expansion and adipogenic ... Cited by 79 - Related articles - BL Direct - All 7 versions
- ►endojournals.org L Khamzina, A Veilleux, S Bergeron, A … - Endocrinology, 2005 - Endocrine Soc The mammalian target of rapamycin (mTOR) pathway integrates insulin and nutrient
signaling in numerous cell types. Recent studies also suggest that this pathway
negatively modulates insulin signaling to phosphatidylinositol 3-kinase/Akt ... Cited by 87 - Related articles - All 7 versions
