L Vence, C Benoist, D Mathis - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease wherein autoreactive T-cells promote the specific
destruction of pancreatic islet β-cells. Evidence for a crucial role for Fas/FasL interactions in this
destruction has been highly controversial because of the pleiotropic effects of Fas ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►rupress.org I Apostolou, Z Hao, K Rajewsky, H von … - Journal of Experimental …, 2003 - jem.rupress.org In type 1 diabetes, autoimmune T cells cause destruction of pancreatic ß cells by largely unknown
mechanism. Previous analyses have shown that ß cell destruction is delayed but can occur in
perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not ... Cited by 37 - Related articles - BL Direct - All 5 versions
S Reddy, JM Ross - ANNALS-NEW YORK ACADEMY OF …, 2003 - interscience.wiley.com Abstract: During insulin-dependent diabetes mellitus, beta cell destruction may involve activation
of the Fas-Fas ligand (Fas-FasL) system. Here, we employed dual-label immunohistochemistry
to examine the intra-islet expression, distribution, and cellular sources of Fas and FasL in ... Cited by 8 - Related articles - BL Direct - All 5 versions
S Sainio-Pöllänen, S Erkkilä, S Alanko, A Hänninen, P … - Pancreas, 1998 - journals.lww.com Page 1. Pancreas Vol. 16. No. 2. pp. 154-159 0 1998 Lippincott-Raven Publishers. Philadelphia
The Role of Fas Ligand in the Development of Insulitis in Nonobese Diabetic Mice *TS.
Sainio-Pollanen, *TS. Erkkila, *fS. Alanko, $A. Hanninen, *§P. Pollanen, and TO. Simell ... Cited by 12 - Related articles - BL Direct - All 3 versions
HTC Kreuwel, LA Sherman - Journal of clinical immunology, 2001 - Springer In the past few years a number of studies have evaluated the contributions of different cytolytic
pathways in the autoimmune destruction of pancreatic ß cells, which results in insulin- dependent
(type I) diabetes mellitus. Conflicting results con- tinue to emerge regarding the role of ... Cited by 12 - Related articles - BL Direct - All 4 versions
M Pearl-Yafe, S Iskovich, A Kaminitz, J Stein, I Yaniv, N … - Autoimmunity Reviews, 2006 - Elsevier The initial immune process that triggers autoimmune β cell destruction in type 1 diabetes is not
fully understood. In early infancy there is an increased β cell turnover. Recurrent exposure of
tissue-specific antigens could lead to primary sensitization of immune cells in the draining ... Cited by 6 - Related articles - All 2 versions
- ►amjpathol.org AS Mohamood, ML Guler, Z Xiao, D Zheng, A Hess, Y … - American Journal of …, 2007 - ASIP Spontaneous mutation of Fas (lpr) or FasL (gld) completely protects nonobese diabetic mice
from autoimmune diabetes but also causes massive double-negative T-cell
lymphoproliferation. In this study, we used bone marrow chimeras and adoptive transfer ... Cited by 6 - Related articles - BL Direct - All 11 versions
MS Lee, S Kim, JH Chung, MK Lee, KW Kim - Autoimmunity, 1999 - informahealthcare.com Fas is Expressed in Murine Pancreatic Islet Cells and an ... Insulinoma Cell Line but Does Not
Mediate Their ... MYUNG-SHIK LEE*, SUNSHIN KIM, JAE HOON CHUNG, MOON-KYU LEE
and KWANG-WON KIM ... CD4+ lymphocytes are the most important effector cells in ... Cited by 6 - Related articles - BL Direct - All 5 versions
M Pearl-Yafe, ES Yolcu, I Yaniv, J Stein, H Shirwan, … - BioEssays, 2006 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org R Darwiche, MMW Chong, P Santamaria, HE … - The Journal of …, 2003 - Am Assoc Immnol Fas (CD95) is a potential mechanism of pancreatic cell death in type 1 diabetes. cells do not
constitutively express Fas but it is induced by cytokines. The hypothesis of this study is that Fas
expression should be measurable on cells for them to be killed by this mechanism. We ... Cited by 24 - Related articles - BL Direct - All 4 versions
