S Abdelli, J Ansite, R Roduit, T Borsello, I Matsumoto, T … - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from a progressive decrease in β-cell mass
and function (1). The mediators of β-cell dysfunction and destruction include macrophages,
T-cells and their inflammatory products, such as cytokines (2), and free radicals such as ... Cited by 50 - Related articles - BL Direct - All 8 versions
H Noguchi, Y Nakai, S Matsumoto, M … - American Journal of …, 2005 - ccmjournal.org Although application of the Edmonton protocol has markedly improved outcomes for pancreatic
islet transplantation, the insulin independence rate after islet transplantation from one donor
pancreas has proven to remain low. During the isolation process and subsequent clinical ... Cited by 37 - Related articles - All 7 versions
S Abdelli, A Abderrahmani, BJ Hering, JS Beckmann, C … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis The protocols used for the preparation of human pancreatic islets immediately
induce a sustained and massive activation of the c-Jun-N-terminal kinase (JNK). JNK, which
participates in apoptosis of insulin-secreting cells, is activated by mechanical stresses, as ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in the islets of Langerhans
involving activation of apoptosis and necrosis and the production of proinflammatory molecules
that negatively influence islet yield and function and may produce detrimental effects after ... Cited by 72 - Related articles - BL Direct - All 4 versions
S Paraskevas, R Aikin, D Maysinger, JRT Lakey, TJ … - FEBS letters, 1999 - Elsevier Isolation and purification of islet cells exposes them to ischemic, osmotic and mechanical
stresses. The objective of this study was to determine the roles of the MAP-kinases in islets immediately
following isolation. During the first 48 h, activity of JNK1 and JNK2 declined markedly. ... Cited by 53 - Related articles - All 8 versions
H Noguchi, Y Nakai, M Ueda, Y Masui, S Futaki, N … - Diabetologia, 2007 - Springer Page 1. ARTICLE Activation of c-Jun NH 2 -terminal kinase (JNK) pathway during islet
transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor H. Noguchi
& Y. Nakai & M. Ueda & Y. Masui & S. Futaki & N. Kobayashi & S. Hayashi & S. Matsumoto ... Cited by 15 - Related articles - BL Direct - All 6 versions
A Ammendrup, A Maillard, K Nielsen, NA … - DIABETES-NEW …, 2000 - Am Diabetes Assoc To characterize the differentiation events that selec- tively target insulin-producing cells to interleukin
(IL)- 1 –induced apoptosis, we studied IL-1 signaling via mitogen-activated protein kinase
(MAPK) and stress- activated protein kinase in 2 pancreatic endocrine cell lines. We ... Cited by 110 - Related articles - BL Direct - All 4 versions
T Matsuda, K Omori, T Vuong, M Pascual, … - American Journal of …, 2005 - interscience.wiley.com Nonspecific inflammation is associated with primary graft nonfunction (PNF). Inflammatory islet
damage is mediated at least partially by pro-inflammatory cytokines, such as interleukin-1β
(IL-1β) and tumor necrosis factor-α (TNF-α) produced by resident islet macrophages. The ... Cited by 40 - Related articles - All 4 versions
- ►diabetesresearch.org [PDF] A Fornoni, L Cobianchi, NY Sanabria, A Pileggi, RD … - … and biophysical research …, 2007 - Elsevier The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired
function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms
of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI ... Cited by 10 - Related articles - All 10 versions
- ►diabetesresearch.org [PDF] D Klein, MM Ribeiro, V Mendoza, S Jayaraman, NS … - … and Biophysical Research …, 2004 - Elsevier Viability of isolated islets is one of the main obstacles limiting islet transplantation success. It
has been reported that overexpression of Bcl-2/Bcl-XL proteins enhances islet viability. To avoid
potential complications associated with long-term expression of anti-apoptotic proteins, ... Cited by 41 - Related articles - All 5 versions
