J Matsui, Y Terauchi, N Kubota, I Takamoto, K Eto, T … - Diabetes, 2004 - Am Diabetes Assoc Heterozygous peroxisome proliferator–activated receptor-γ (PPAR-γ)-deficient (PPARγ +/− )
mice were protected from high-fat diet–induced insulin resistance. To determine the impact of
systemic reduction of PPAR-γ activity on β-cell function, we investigated insulin secretion ... Cited by 42 - Related articles - BL Direct - All 4 versions
[CITATION] Assays to measure stress-activated mitogen-activated protein kinase activity
C Caelles, M Morales - Apoptosis Methods and Protocols. Brady HJM, Ed. …, 2004 Cited by 4 - Related articles
MH Tan, A Baksi, B Krahulec, P Kubalski, A … - Diabetes Care, 2005 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—This was a randomized, multicenter, double-blind,
double-dummy, parallel-group, 2-year study. Approximately 600 patients from 98 centers
participated. Eligible patients had completed a previous 12-month study and consented to ... Cited by 51 - Related articles - All 6 versions
- ►physiology.org R Lupi, S Del Guerra, L Marselli, M … - American Journal of …, 2004 - Am Physiological Soc Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the superfamily of nuclear
receptors, with three distinct main types: , and (subdivided into 1 and 2 ). Recently, the presence
of PPAR has been reported in human islets. Whether other PPAR types can be found in ... Cited by 79 - Related articles - BL Direct - All 4 versions
- ►endojournals.org CY Lin, T Gurlo, L Haataja, WA Hsueh, PC … - Journal of Clinical …, 2005 - Endocrine Soc Methods and Results: Vehicle or h-IAPP was applied to human islets with or without RSG (10
and 50 µM) for 48 h. A 2-fold increase in the number of terminal deoxynucleotidyl
transferase-mediated deoxy-UTP nick end labeling-positive nuclei was detected in ... Cited by 37 - Related articles - BL Direct - All 4 versions
H Kaneto - Expert Opin. Ther. Targets, 2005 - informahealthcare.com The hallmark of Type 2 diabetes is insulin resistance and pancreatic β-cell dys- function. Under
diabetic conditions, the c-jun N-terminal kinase (JNK) path- way is activated in various
tissues, which is involved in both insulin resistance and β-cell dysfunction. Activation of ... Cited by 12 - Related articles - BL Direct - All 5 versions
J Ogawa, S Takahashi, T Fujiwara, J Fukushige, T … - Life sciences, 1999 - Elsevier Recent investigations suggest that cytotoxic cytokines such as tumor necrosis factor (TNF)α and
interleukin (IL)-1β or free radicals play an essential role in destruction of pancreatic β cells in
Type 1 diabetes and that, therefore, anti-oxidant or anti-TNFα and IL-1β therapy could ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►endojournals.org AH Xiang, RK Peters, SL Kjos, J Goico, C … - Journal of Clinical …, 2004 - Endocrine Soc During a mean follow-up of 4.3 yr between baseline and posttrial tests, glucose tolerance (oral
glucose tolerance test glucose area, P = 0.04) and insulin resistance (MINMOD S I , P =
0.02) worsened more in women randomized to late intervention (n = 69) than to early ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►endojournals.org E Zeender, K Maedler, D Bosco, T Berney, MY … - Journal of Clinical …, 2004 - Endocrine Soc Decreased functional ß-cell mass in type 1 and type 2 diabetes is due to ß-cell apoptosis and
impaired secretory function suggested to be mediated, in part, by immune- and/or
high-glucose-induced production of IL-1ß acting through the nuclear factor B (NF B)/Fas ... Cited by 75 - Related articles - BL Direct - All 4 versions
- ►physiology.org F Kawasaki, M Matsuda, Y Kanda, H … - American Journal of …, 2005 - Am Physiological Soc To evaluate preventive effects of pioglitazone on pancreatic -cell damage in C57BL/KsJ db/db
mice, an obese diabetic animal model, the pancreatic islets were compared morphologically
between pioglitazone-treated (100 mg/kg daily po) and untreated db/db mice (n = 7 for ... Cited by 32 - Related articles - All 4 versions
