- ►diabetesjournals.org H Zhao, S Yakar, O Gavrilova, H Sun, Y Zhang … - Diabetes, 2004 - Am Diabetes Assoc The chronic hyperglycemia that occurs in type 2 diabetes may cause deterioration
of β-cell function and insulin resistance in peripheral tissues. Mice that
express a dominant-negative IGF-1 receptor, specifically in skeletal muscle ... Cited by 20 - Related articles - BL Direct - All 4 versions
Y Brunner, D Schvartz, F Priego-Capote, Y … - Journal of Proteomics, 2009 - Elsevier Chronic hyperglycaemia is one of the main characteristics of a diabetic state.
This is also the first cause of diabetic complications. However, it is now
generally accepted that glucotoxicity also participates in the worsening of ... Cited by 1 - Related articles - All 2 versions
- ►endojournals.org L Heron-Milhavet, M Haluzik, S Yakar, O … - Endocrinology, 2004 - Endocrine Soc Insulin resistance is one of the primary characteristics of type 2 diabetes.
Mice overexpressing a dominant-negative IGF-I receptor specifically in muscle
(MKR mice) demonstrate severe insulin resistance with high levels of serum ... Cited by 25 - Related articles - BL Direct - All 5 versions
DE Grobbee - Metabolism, 2003 - Elsevier Patients suffering from type 2 diabetes are at increased risk of macrovascular
and microvascular disease. This review assesses the available evidence for
hypertension and hyperglycemia as risk factors for vascular disease in type ... Cited by 5 - Related articles - All 11 versions
- ►endojournals.org P Pennisi, O Gavrilova, J Setser-Portas, W … - Endocrinology, 2006 - Endocrine Soc IGF-I and insulin are structurally related polypeptides that mediate a similar
pattern of biological effects via receptors that display considerably homology.
Administration of recombinant human IGF-I (rhIGF-I) has been proven to ... Cited by 19 - Related articles - BL Direct - All 5 versions
M Kamalesh - Journal of Cardiac Failure, 2007 - Elsevier Although multiple mechanisms are responsible for development of CHF in diabetes,
ischemic heart disease plays a major role. In the foreseeable future, physicians
will have to deal with increasing numbers of subjects with diabetes, ... Cited by 9 - Related articles - All 13 versions
CS Thompson - Current pharmaceutical design, 2008 - ingentaconnect.com Abstract: The prevalence of diabetes mellitus is increasing worldwide at an
alarming rate due to population growth, obesity, sedentary lifestyle and aging.
Consequently, diabetic microvascular complications (retinopathy and ... Cited by 10 - Related articles - BL Direct - All 3 versions
D Le Roith, H Kim, AM Fernandez, D Accili - Current Opinion in Clinical Nutrition & Metabolic Care, 2002 - journals.lww.com Recent findings: Insulin resistance is often the first abnormality detected in
cases of type 2 diabetes, and is seen at the level of the peripheral tissues
especially muscle. Both the insulin receptor and the insulin-like growth ... Cited by 10 - Related articles - BL Direct - All 2 versions
G Misciagna, GD Michele, M Trevisan - Current Pharmaceutical Design, 2007 - ingentaconnect.com Abstract: The study of the role of glycemia in the causation of cardiovascular
disease has been limited by several factors, above all by its measurement over
time. Non enzymatic glycated proteins in the blood, the product of the non ... Cited by 11 - Related articles - BL Direct - All 2 versions
T Yokozawa, T Nakagawa, T Oya, T Okubo, … - Journal of Pharmacy and Pharmacology, 2005 - ingentaconnect.com Page 1. 773 JPP 2005, 57: 773–780 ß 2005 The Authors Received December 11, 2004
Accepted February 10, 2005 DOI 10.1211/0022357056154 ISSN 0022-3573 ... Cited by 12 - Related articles - All 3 versions
