C Zhang, J Yang, LK Jennings - Diabetes, 2004 - Am Diabetes Assoc Vascular non–leukocyte-derived reactive oxygen species (ROS), such as superoxide and hydrogen
peroxide (H 2 O 2 ), have emerged as important molecules in diabetic endothelial
dysfunction. In addition, leukocyte-derived myeloperoxidase (MPO) has been implicated ... Cited by 30 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org R Stocker, A Huang, E Jeranian, JY Hou, TT … - … , and vascular biology, 2004 - Am Heart Assoc Methods and Results— Rabbit arterial rings exposed to HOCl (0 to 500 µmol/L) exhibited
dose- and time-dependent impairment of endothelium-dependent arterial relaxation to acetylcholine
and A23187, but not the NO donor, diethylamine NONOate, suggesting that HOCl targets ... Cited by 22 - Related articles - BL Direct - All 8 versions
- ►physiology.org C Zhang, J Yang, JD Jacobs, LK … - American Journal of …, 2003 - Am Physiological Soc Vascular NAD(P)H oxidase-derived reactive oxygen species (ROS) such as hydrogen peroxide
(H 2 O 2 ) have emerged as important molecules in the pathogenesis of atherosclerosis,
hypertension, and diabetic vascular complications. Additionally, myeloperoxidase (MPO), ... Cited by 37 - Related articles - BL Direct - All 3 versions
[CITATION] Hypochlorous acid mediated oxidation of lipid components present in low-density …
J Takeshita, J Byun, TQ Nhan, DK Pritchard, S … - Journal of Biological …, 2006 - ASBMB Somatic mutations induced by oxidative damage of DNA might play important roles in
atherogenesis. However, the underlying mechanisms remain poorly understood.
Myeloperoxidase, a heme protein expressed by select populations of artery wall ... Cited by 8 - Related articles - BL Direct - All 6 versions
- ►jbc.org C Zhang, C Reiter, JP Eiserich, B Boersma, DA … - Journal of Biological …, 2001 - ASBMB The myeloperoxidase-derived oxidant hypochlorous acid (HOCl) is thought to contribute to endothelial
dysfunction, but the mechanisms underlying this inhibitory effect are unknown. The present study
tested the hypothesis that HOCl and L-arginine (L-Arg) react to form novel compounds ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►physiology.org C Zhang, R Patel, JP Eiserich, F Zhou, S … - American Journal of …, 2001 - Am Physiological Soc The myeloperoxidase (MPO)-derived oxidant hypochlorous acid (HOCl) plays a role in tissue
injury under inflammatory conditions. The present study tests the hypothesis that HOCl decreases
nitric oxide (NO) bioavailability in the vasculature of Sprague-Dawley rats. Aortic ring ... Cited by 36 - Related articles - BL Direct - All 3 versions
MD Rees, MJ Davies - J. Am. Chem. Soc, 2006 - pubs.acs.org The highly basic heme enzyme myeloperoxidase (MPO), which is released by activated
phagocytes, catalyzes the production of the potent oxidant hypochlorite (HOCl) from H 2 O 2
and chloride ions (Cl - ). Heparan sulfate proteoglycans are key components of the ... Cited by 10 - Related articles - All 4 versions
- ►jimmunol.org JG Wang, SA Mahmud, J Nguyen, A … - The Journal of …, 2006 - Am Assoc Immnol Both eosinophil peroxidase (EPO) and neutrophil myeloperoxidase (MPO) preferentially oxidize
SCN – to generate HOSCN, a weak, sulfhydryl-reactive oxidant, as a major physiologic
product. We here show that HOSCN is a uniquely potent phagocyte oxidant inducer of E- ... Cited by 10 - Related articles - BL Direct - All 5 versions
