- ►diabetesjournals.org HL Zhao, PCY Tong, FMM Lai, B Tomlinson, … - Diabetes, 2004 - Am Diabetes Assoc The expression of nephropathy in type 2 diabetes has several levels of
abnormalities. To define the primary abnormalities of diabetic nephropathy, we
conducted an autopsy study of 186 consecutive patients with type 2 diabetes ... Cited by 13 - Related articles - BL Direct - All 5 versions
M Lajer, L Tarnow, J Fleckner, BV Hansen, … - Diabetic Medicine, 2004 - interscience.wiley.com Aims The Z−2 allele of the (AC) n polymorphism in the aldose reductase gene
(ALR2) confers increased risk of microvascular diabetic complications, whereas
the Z+2 allele has been proposed to be a marker of protection. However data ... Cited by 20 - Related articles - BL Direct - All 4 versions
[CITATION] Development of complications in diabetic dogs and galactosemic dogs: effect of aldose …
TS Kern, RL Engerman - Proceedings of a workshop on aldose reductase …, 1991 Cited by 3 - Related articles
JP Szaflik, I Majsterek, M Kowalski, P Rusin, A … - Experimental Eye Research, 2008 - Elsevier Diabetic retinopathy (DR) may affect 98% of diabetic patients, but its aetiology
is poorly understood. Besides glycaemic exposure, genetic factors likely
contribute to the onset of DR. The polyol pathway, including aldose ... Cited by 3 - Related articles - All 5 versions
HT Zhao, I Hazemann, A Mitschler, V Carbone, … - Journal of Medicinal Chemistry, 2008 - pubs.acs.org In this study we report the structure of ALR2 holoenzyme complexed with the 2S4R
stereoisomer of Fidarestat (Scheme 2) determined with X-ray diffraction data
collected at a temperature of 15 K and refined at 0.78 Å resolution. The ... Cited by 3 - Related articles - All 3 versions
D Rakowitz, G Piccolruaz, C Pirker, B … - Archiv der Pharmazie, 2007 - interscience.wiley.com Starting from the recently identified aldose reductase inhibitor
6-[[(diphenylmethylene)amino]oxy]hexanoic acid 1, the following systematic
structural modifications were performed: (a) formal substitution of the ... Cited by 4 - Related articles - BL Direct - All 4 versions
JP Kassab, R Guillot, J Andre, N Claperon, G … - Biochemical pharmacology, 1994 - ncbi.nlm.nih.gov Aldose reductase inhibitors, and particularly sorbinil, have been reported to
prevent glomerular basement membrane thickening (GBMT) and albuminuria
development in diabetic rats, but contradictory observations have been ... Cited by 7 - Related articles - BL Direct - All 2 versions
M Nakahara, K Miyata, S Otani, T Miyai, R … - British Journal of Ophthalmology, 2005 - bjo.bmj.com Methods: This was a prospective, randomised, double masked placebo controlled
study. 34 eyes of 34 diabetic patients were randomly assigned treatment with
0.25% eye drops of CT-112 (n = 22) or a placebo (n = 12) four times a day ... Cited by 10 - Related articles - All 10 versions
H Suzuki, T Shimosegawa, S Ohara, T Toyota - Journal of gastroenterology, 1999 - Springer Because chronic hyperglycemia is associated with systemic micro-circulatory
disturbances, 1 some changes may also occur in gastric mucosal blood flow (GMBF)
in diabetic patients. However, whether diabetic patients are more ... Cited by 11 - Related articles - BL Direct - All 5 versions
K Utsunomiya, I Narabayashi, K Tamura, Y … - European Journal of Nuclear Medicine and Molecular …, 1998 - Springer Page 1. Original article Effects of aldose reductase inhibitor and vitamin B
12 on myocardial uptake of iodine-123 metaiodobenzylguanidine ... Cited by 13 - Related articles - BL Direct - All 4 versions
