JL Bento, ND Palmer, JC Mychaleckyj, LA … - Diabetes, 2004 - Am Diabetes Assoc The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48),
which negatively regulates insulin signaling by dephosphorylating the
phosphotyrosine residues of the insulin receptor kinase activation segment. ... Cited by 69 - Related articles - BL Direct - All 6 versions
ND Palmer, JL Bento, JC Mychaleckyj, CD … - DIABETES-NEW YORK-, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the
dephosphorylation of pro- teins at tyrosyl residues. PTP-1B has been implicated
in negatively regulating insulin signaling by dephosphory- lating the ... Cited by 45 - Related articles - BL Direct - All 6 versions
JC Florez, CM Agapakis, NP Burtt, M Sun, P … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates
the insulin signal transduction cascade by dephosphorylating phosphotyrosine
residues in insulin signaling molecules. Due to its chromosomal location ... Cited by 25 - Related articles - All 8 versions
SM Echwald, H Bach, H Vestergaard, B … - Diabetes, 2002 - Am Diabetes Assoc In the present study, we tested the hypothesis that variability in the protein
tyrosine phosphatase-1B (PTP-1B) gene is associated with type 2 diabetes. Using
single-strand conformational polymorphism analysis, we examined cDNA of ... Cited by 71 - Related articles - BL Direct - All 4 versions
- ►nih.gov R Di Paola, L Frittitta, G Miscio, M Bozzali, R … - The American Journal of Human Genetics, 2002 - Elsevier Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when
overexpressed, plays a role in insulin resistance (Ahmad et al. 1997). We
identified, in the 3′ untranslated region of the PTP1B gene, a 1484insG ... Cited by 104 - Related articles - BL Direct - All 4 versions
NJ Spencer-Jones, X Wang, H Snieder, TD … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase-1B negatively regulates leptin and insulin
signaling, potentially contributing to hormonal resistance. We selected six
tagging single nucleotide polymorphisms (SNPs) representing 18 common ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Mok, H Cao, B Zinman, AJG Hanley, SB … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Several lines of evidence support a role for protein tyrosine phosphatase 1B
(PTP-1B) in metabolism, and specifically in insulin sensitivity and obesity. We
report the development of reagents for the amplification and sequencing of ... Cited by 64 - Related articles - BL Direct - All 6 versions
I Dahlman, H Wahrenberg, L Persson, P Arner - Journal of internal medicine, 2004 - cat.inist.fr No association of reported functional protein tyrosine phosphatase 1 B 3' UTR gene
polymorphism with features of the metabolic syndrome in a Swedish population. ... Cited by 10 - Related articles - BL Direct - All 3 versions
S Kipfer-Coudreau, D Eberle, M Sahbatou, A … - Diabetologia, 2004 - Springer Aims/hypothesis. The development of insulin resis- tance may contribute to the
occurrence and progres- sion of the metabolic syndrome associated with obesi-
ty. Components contributing to the insulin pathway and its regulation are ... Cited by 11 - Related articles - BL Direct - All 4 versions
