D Smyth, JD Cooper, JE Collins, JM Heward, … - Diabetes, 2004 - Am Diabetes Assoc In the genetic analysis of common, multifactorial diseases, such as type 1
diabetes, true positive irrefutable linkage and association results have been
rare to date. Recently, it has been reported that a single nucleotide ... Cited by 244 - Related articles - BL Direct - All 5 versions
MR Velaga, V Wilson, CE Jennings, CJ Owen, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc The lymphoid tyrosine phosphatase (LYP), encoded by the protein tyrosine
phosphatase-22 (PTPN22) gene, is a powerful inhibitor of T cell activation.
Recently, a single nucleotide polymorphism (SNP), encoding a functional ... Cited by 176 - Related articles - BL Direct - All 4 versions
- ►nih.gov C Kyogoku, WA Ortmann, A Lee, S Selby, VEH … - The American Journal of Human Genetics, 2004 - Elsevier Systemic lupus erythematosus (SLE [MIM 152700]) is a chronic and severe systemic
autoimmune disease associated with high titers of antinuclear antibodies and
clinical involvement of many different organs and tissues, including skin, ... Cited by 272 - Related articles - BL Direct - All 10 versions
- ►nih.gov AB Begovich, VEH Carlton, LA Honigberg, SJ … - The American Journal of Human Genetics, 2004 - Elsevier Rheumatoid arthritis (RA) is the most common systemic autoimmune disease,
affecting 1% of the adult population worldwide, with an estimated heritability
of 60%. To identify genes involved in RA susceptibility, we investigated ... Cited by 525 - Related articles - BL Direct - All 9 versions
S Onengut-Gumuscu, KG Ewens, RS … - Genes and immunity, 2004 - nature.com Type I diabetes (T1D) is a complex disorder, which arises from the autoimmune
destruction of the insulin-secreting cells of the pancreas leading to a
life-long dependence on exogenous insulin. A recent study of T1D cases and ... Cited by 70 - Related articles - All 2 versions
- ►pasteur.ac.ir [PDF] MB Ladner, N Bottini, AM Valdes, JA Noble - Human immunology, 2005 - Elsevier The PTPN22 (protein tyrosine phosphatase N22) gene encodes the protein tyrosine
phosphatase Lyp. One function of Lyp is downregulation of T-cell signaling
through its interaction with the negative regulatory kinase C-terminal Src ... Cited by 72 - Related articles - All 4 versions
- ►pubget.com [PDF] BJ Barratt, F Payne, CE Lowe, R Hermann, BC … - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes susceptibility at the IDDM2 locus was previously mapped to a
variable number tandem repeat (VNTR) 5' of the insulin gene (INS). However, the
observation of associated markers outside a 4.1-kb interval, previously ... Cited by 111 - Related articles - BL Direct - All 6 versions
W Zheng, JX She - Diabetes, 2005 - Am Diabetes Assoc The lymphoid-specific phosphatase (LYP) encoded by PTPN22 is involved in
preventing spontaneous T-cell activation by dephosphorylating and inactivating
T-cell receptor-associated Csk kinase. We have genotyped 396 type 1 ... Cited by 63 - Related articles - All 5 versions
- ►nih.gov LA Criswell, KA Pfeiffer, RF Lum, B Gonzales … - The American Journal of Human Genetics, 2005 - Elsevier Autoimmune disorders constitute a diverse group of phenotypes with overlapping
features and a tendency toward familial aggregation. It is likely that common
underlying genes are involved in these disorders. Until very recently, no ... Cited by 207 - Related articles - All 19 versions
