SH Bates, TA Dundon, M Seifert, M Carlson, E Maratos- … - Diabetes, 2004 - Am Diabetes Assoc Secretion of leptin from adipose tissue communicates body energy status to the neuroendocrine
system by activating the long form of the leptin receptor (LRb). Lack of leptin or LRb (as in
db/db mice) results in obesity that stems from the combined effects of hyperphagia and ... Cited by 41 - Related articles - BL Direct - All 4 versions
SH Bates, RN Kulkarni, M Seifert, MG Myers - Cell Metabolism, 2005 - Elsevier Leptin activates the long form of the leptin receptor (LRb) to control feeding and neuroendocrine
function and thus regulate adiposity. While adiposity influences insulin sensitivity, leptin also
regulates glucose homeostasis independently of energy balance. Disruption of the LRb/ ... Cited by 42 - Related articles - All 9 versions
- ►jbc.org Y Gong, R Ishida-Takahashi, EC Villanueva, DC … - Journal of Biological …, 2007 - ASBMB The action of leptin via the long form of its receptor (LepRb) is central to the control of body energy
homeostasis and neuroendocrine function, but the mechanisms by which LepRb regulates intracellular
signaling have remained incompletely understood. Here we demonstrate that leptin ... Cited by 21 - Related articles - All 6 versions
- ►nih.gov M Björnholm, H Münzberg, RL Leshan, EC … - Journal of Clinical …, 2007 - Am Soc Clin Investig The adipose-derived hormone, leptin, acts via its receptor (LRb) to convey the status of body
energy stores to the brain, decreasing feeding and potentiating neuroendocrine energy
expenditure. The failure of high levels of leptin in most obese individuals to promote ... Cited by 26 - Related articles - BL Direct - All 9 versions
JK Elmquist, R Coppari, N Balthasar, M … - Journal of …, 2005 - interscience.wiley.com The past decade has greatly increased our understanding and appreciation of the ability of the
central nervous system (CNS) to regulate food intake and body weight. This was spearheaded
by the discovery of key molecules regulating body weight homeostasis. It is now also ... Cited by 73 - Related articles - BL Direct - All 4 versions
P Hekerman, J Zeidler, S Bamberg-Lemper, H … - FEBS …, 2005 - interscience.wiley.com The leptin receptor (LEPR) is a class I cytokine receptor signalling via both the janus kinase/signal
transducer and activator of transcription (JAK/STAT) and the MAP kinase pathways. In
addition, leptin has been shown previously to activate AMP-activated kinase (AMPK) in ... Cited by 39 - Related articles - All 2 versions
Q Gao, MJ Wolfgang, S Neschen, K … - Proceedings of the …, 2004 - National Acad Sciences Signal transducer and activator of transcription (STAT)3 is widely expressed in the CNS during
development and adulthood. STAT3 has been implicated in the control of neuron/glial differentiation
and leptin-mediated energy homeostasis, but the physiological role and degree of ... Cited by 121 - Related articles - BL Direct - All 11 versions
- ►cell.com R Coppari, M Ichinose, CE Lee, AE Pullen, CD Kenny, … - Cell metabolism, 2005 - Elsevier Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus
(ARH) has been proposed as an important site of leptin action. To assess the physiological significance
of leptin signaling in the ARH, we used mice homozygous for a FLPe-reactivatable, leptin ... Cited by 102 - Related articles - All 12 versions
- ►cell.com SH Bates, MG Myers - Trends in Endocrinology & Metabolism, 2003 - Elsevier The adipose-derived hormone leptin regulates energy balance and neuroendocrine
function, and resistance to its appetite-suppressing effects might underlie common forms of
obesity. Understanding the intracellular signaling pathways and hypothalamic neural ... Cited by 81 - Related articles - All 15 versions
RL Leshan, M Björnholm, H Münzberg, MG Myers - Obesity, 2006 - nature.com The increasing incidence of obesity in developed nations represents an ever-growing challenge
to health care by promoting diabetes and other diseases. The discovery of the hormone,
leptin, a decade ago has facilitated the acquisition of new knowledge regarding the ... Cited by 25 - Related articles - All 4 versions
